- Search results for K08865
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44 products were found matching "K08865"!
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Item number: Cay17052-500
OTS964 is an inhibitor of lymphokine-activated killer T cell-originated protein kinase (TOPK, IC50 = 28 nM). It specifically blocks cytokinesis, leading to apoptosis, in a broad range of cancer cells. OTS964 induces apoptosis of human lung cancer cells in mouse xenografts.Formal Name:...
Keywords: | 9-[4-[(1R)-2-(dimethylamino)-1-methylethyl]phenyl]-8-hydroxy-6-methyl-thieno[2,3-c]quinolin-4(5H)-one, monohydrochloride |
Application: | PBK / TOPK inhibitor |
CAS | 1338545-07-5 |
MW: | 429 D |
From 66.00€
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Item number: Cay19815-5
HI TOPK 032 is an inhibitor of lymphokine-activated killer T cell-originated protein kinase (TOPK), blocking phosphorylation of the substrate histone H2AX with an IC50 value of ~2 µM and providing complete inhibition at 5 µM. It also inhibits checkpoint kinase 1 (Chk1, IC50 = 9.6 µM). In addition, HI TOPK 032...
Keywords: | N-(12-cyanoindolizino[2,3-b]quinoxalin-2-yl)-2-thiophenecarboxamide |
Application: | PBK inhibitor |
CAS | 487020-03-1 |
MW: | 369.4 D |
From 46.00€
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Item number: A302-194A
Protein function: Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. [The UniProt...
Keywords: | Anti-PBK, Anti-SPK, Anti-TOPK, Anti-CT84, Anti-Nori-3, EC=2.7.12.2, Anti-PDZ-binding kinase, Anti-Cancer/testis antigen... |
Application: | WB, IP |
Host: | Rabbit |
Species reactivity: | human |
From 164.00€
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Item number: A302-195A
Protein function: Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. [The UniProt...
Keywords: | Anti-PBK, Anti-SPK, Anti-TOPK, Anti-CT84, Anti-Nori-3, EC=2.7.12.2, Anti-PDZ-binding kinase, Anti-Cancer/testis antigen... |
Application: | WB, IP, IHC |
Host: | Rabbit |
Species reactivity: | human |
From 164.00€
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Item number: NSJ-R31723
0.5mg/ml if reconstituted with 0.2ml sterile DI water. PDZ binding kinase (PBK), also known as TOPK, is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. PBK can mediate cell growth through histone H3 modification. Evidence suggests that mitotic...
Keywords: | Anti-SPK, Anti-PBK, Anti-TOPK, Anti-CT84, Anti-Nori-3, EC=2.7.12.2, Anti-PDZ-binding kinase, Anti-Cancer/testis antigen... |
Application: | WB, IHC (paraffin), IF/ICC, FC |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
755.00€
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Item number: ARG57886.100
Protein function: Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. [The UniProt...
Keywords: | Anti-SPK, Anti-PBK, Anti-TOPK, Anti-CT84, Anti-Nori-3, EC=2.7.12.2, Anti-PDZ-binding kinase, Anti-Cancer/testis antigen... |
Application: | WB |
Host: | Rabbit |
Species reactivity: | human |
624.00€
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Item number: Cay17053-1
OTS514 is an inhibitor of lymphokine-activated killer T cell-originated protein kinase (TOPK, IC50 = 2.6 nM), a serine-threonine kinase often overexpressed and transactivated in several types of cancer. OTS514 (10 nM) selectively inhibits growth of patient-derived acute myeloid leukemia (AML) cells over normal CD34+...
Keywords: | 9-[4-[(1R)-2-amino-1-methylethyl]phenyl]-8-hydroxy-6-methyl-thieno[2,3-c]quinolin-4(5H)-one |
Application: | TOPK inhibitor |
CAS | 1338540-63-8 |
MW: | 364.5 D |
From 125.00€
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Item number: ARG57923.100
Protein function: Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. [The UniProt...
Keywords: | Anti-phospho-PBK, Anti-phospho-SPK, Anti-phospho-CT84, Anti-phospho-TOPK, Anti-phospho-Nori-3, EC=2.7.12.2,... |
Application: | WB |
Host: | Rabbit |
Species reactivity: | human |
584.00€
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Item number: ARG57922.100
Protein function: Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization. [The UniProt Consortium]
Keywords: | Anti-Pbk, Anti-Topk, EC=2.7.12.2, Anti-PDZ-binding kinase, Anti-T-LAK cell-originated protein kinase,... |
Application: | IHC (paraffin), WB |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
584.00€
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Item number: G-CBCAB01353.96
PBK/TOPK (Phospho-Thr9) Colorimetric Cell-Based ELISA Kit Protein function: Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint...
Keywords: | PBK, SPK, TOPK, CT84, Nori-3, EC=2.7.12.2, PDZ-binding kinase, Cancer/testis antigen 84, MAPKK-like protein kinase, T-LAK... |
Application: | In-cell ELISA |
641.00€
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Item number: G-CAB4852.100
Application: | WB |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
From 352.00€
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Item number: G-CAB19947.100
Protein function: Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin- induced DNA damage. [The UniProt...
Keywords: | Anti-PBK, Anti-SPK, Anti-TOPK, Anti-CT84, Anti-Nori-3, EC=2.7.12.2, Anti-PDZ-binding kinase, Anti-Cancer/testis antigen... |
Application: | WB, IHC |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
From 352.00€
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