32 products were found matching "K08863"!

RP 1664 is an inhibitor of polo-like kinase 4 (Plk4, IC50 = 3 nM). It induces centriole depletion in hTERT RPE-1 retinal pigment cells (EC50 = 0. µM). RP 1664 induces cytotoxicity in MCF-7 breast cancer cells (EC50 = 0. µM). It reduces tumor volume in a CAL-148 breast cancer mouse xenograft model when administered...

Centrinone is an inhibitor of polo-like kinase 4 (Plk4, Ki = 0.16 nM). It is greater than 1,100- and 2,800-fold selective for Plk4 over Aurora A and Aurora B kinases, respectively, and a panel of 442 kinases at 100 nM. Centrinone (125 nM) depletes centrosomes and induces apoptosis in HeLa cells.Formal Name:...

Human polo-like kinase 4 (PLK4), also known as serine/threonine protein kinase 18 (STK18), SAK, GenBank Accession No. NM_014264, a.a. 1-836 with an N-terminal GST-tag, expressed in a baculovirus-infected Sf9 cell expression system. MW = 140 kDa.

PLK4 inhibitor.

CFI-400437 is a potent PLK4 inhibitor (IC50=0.6nM) and selective against other members of the PLK family (>10µM). Against a broad panel of kinases, only a small subset is significantly inhibited. CFI-400437 is a potent inhibitor of MCF-7, MDA-MB-468 and MDA-MB-231 cell growth and very effective in a mouse xenograft...

Protein function: Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When...

This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein...

Protein function: Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When...

Protein function: Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When...

Protein function: Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When...

Description: Centrinone (LCR-263) (LCR-263) is a reversible inhibitor of polo-like kinase 4 (PLK4, Ki:0.16 nM). Target: Aurora Kinase, PLK. Smiles: COc1c(Nc2cc(C)[nH]n2)nc(Sc2ccc(cc2F)S(=O)(=O)Cc2cccc(c2F)[N+]([O-])=O)nc1N1CCOCC1. References: Wong YL. et al. Cell biology. Reversible centriole depletion with an...

Description: CFI-400945 is an potent, selective and orally active inhibitor of polo-like kinase 4(PLK4, Ki value of 0.26 nM). Target: PLK. Smiles: O=C1[C@]2([C@@H](C2)C=3C=C4C(=CC3)C(/C=C/C5=CC=C(CN6C[C@@H](C)O[C@@H](C)C6)C=C5)=NN4)C=7C(N1)=CC=C(OC)C7. References: Mason J , Lin D C , Wei X , et al. Functional...