49 products were found matching "K08765"!

(+)-Etomoxir is an irreversible inhibitor of carnitine palmitoyltransferase 1 (CPT1), an enzyme that combines fatty acyl-CoAs with carnitine for transport into the mitochondria for beta-oxidation. It inhibits fatty acid oxidation in hepatocytes in vitro (IC50s = 0.1, 1, and 10 µM for human, guinea pig, and rat...

(+)-Etomoxir is an inhibitor of carnitine palmitoyltransferase 1 (CPT1) and a prodrug form of (+)-etomoxir (Cay-11969). It is an ethyl ester that is cleaved by intracellular esterases to release the active inhibitor of CPT1. (+)-Etomoxir decreases palmitate (Cay-10010279) oxidation and increases glucose oxidation in...

Perhexiline is a carnitine palmitoyltransferase 1 (CPT1) and CPT2 inhibitor that was originally developed as an anti-anginal drug in the 1970s. It inhibits rat heart and liver CPT1 (IC50 = 77 and 148 µM, respectively) and rat heart CPT2 (IC50 = 79 µM). Inhibition of CPT reduces uptake of long-chain fatty acids into...

Irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1a) a mitochondrial enzyme involved in fatty acid beta-oxidation. CPR-1a on the outer face of the inner mitochondrial membrane, consequently prevents the formation of acyl carnitines, a step that is necessary for the transport of fatty acyl chains from...

Oxfenicine is an inhibitor of carnitine palmitoyltransferase 1 (CPT1) and a prodrug form of 4-hydroxyphenylglyoxylic acid. Oxfenicine is transaminated to 4-hydroxyphenylglyoxylic acid by branched-chain amino acid aminotransferase in rat heart homogenates. It inhibits fatty acid oxidation and increases carbohydrate...

Protein function: Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Plays an important role in triglyceride metabolism. [The UniProt...

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Carnitine palmitoyltransferase 1A Protein function: Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial...

In 1X PBS, pH 7.4, with 0.09% sodium azide. The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane...

Palmitoyl-D-carnitine is a long-chain acylcarnitine, an isomer of palmitoyl-L-carnitine (Cay-26553), and the D enantiomer of palmitoyl-DL-carnitine (Cay-11095). It inhibits carnitine palmitoyltransferase with a Ki value of 2.1 mM for 14C-palmitoylcarnitine synthesis by erythrocyte membranes.Formal Name:...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner...

4-Hydroxyphenylglyoxylic acid is an inhibitor of carnitine palmitoyltransferase 1 (CPT1) and an active metabolite of the prodrug oxfenicine (Cay-33698). It inhibits CPT1 in isolated rat liver mitochondria when used at concentrations ranging from 200 to 1,000 µM and inhibits oleate oxidation in isolated rat...