59 products were found matching "K08537"!

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat FXR. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat FXR. Next, Avidin...

Chenodeoxycholic acid (CDCA) is a hydrophobic primary bile acid. It is formed from cholesterol in the liver via a multistep process catalyzed by the cytochrome P450 (CYP) isoforms CYP7A1, CYP8B1, and CYP27A1. CDCA is a farnesoid X receptor (FXR) agonist that binds to FXRs in a TR-FRET assay (EC50 = 13 µM) and...

Tauro-obeticholic acid is an active metabolite of obeticholic acid, which is a farnesoid X receptor (FXR) agonist and semisynthetic derivative of chenodeoxycholic acid (Cay-10011286). Tauro-obeticholic acid is formed from obeticholic acid by taurine conjugation in the liver but can be reconverted back to obeticholic...

Potent and selective farnesoid X receptor FXR agonist (EC50= 99nM) [1]. Induces SHP in HSCs to suppress TIMP-1 expression [2]. Apoptosis inducer [2]. Protects against liver fibrosis development in rat in vivo [2]. Displays anticholeretic activity in rat in vivo [3]. Promotes preadipocyte differentiation [4]....

Tauro-beta-muricholic acid (TbetaMCA) is a competitive and reversible antagonist of the farnesoid X receptor (FXR, IC50 = 40 µM) and a taurine-conjugated form of the murine-specific primary bile acid beta-muricholic acid (Cay-20287). TbetaMCA accumulates in germ-free mice under normal conditions but is reduced after...

Tauro-alpha-muricholic acid (TalphaMCA) is an antagonist of the farnesoid X receptor (FXR, IC50 = 28 µM) and a taurine-conjugated form of the murine-specific primary bile acid alpha-muricholic acid (Cay-20291). TalphaMCA is common in rodents but has also been found in small amounts in human serum.Formal Name:...

Farnesoid X receptor (FXR) is a nuclear receptor that acts as a bile acid sensor, protecting cells and organs against bile acid toxicity. GW 4064 is a selective agonist of FXR (EC50 = 15 nM). It displays no activity at other nuclear receptors, including the retinoic acid receptor, at concentrations up to 1 µM. GW...

Glycine-beta-muricholic acid (GbetaMCA) is an intestine-selective antagonist of the farnesoid X receptor (FXR) and the glycine-conjugated form of the murine-specific primary bile acid beta-muricholic acid (Cay-20287). It inhibits expression of the FXR target genes Shp and Fgf15 induced by the FXR ligands...

Chenodeoxycholic acid-d4 (CDCA-d4) is intended for use as an internal standard for the quantification of CDCA (Cay-10011286) by GC- or LC-MS. CDCA is a hydrophobic primary bile acid. It is formed from cholesterol in the liver via a multistep process catalyzed by the cytochrome P450 (CYP) isoforms CYP7A1, CYP8B1, and...

White to off-white solid. Soluble in DMSO, ethanol or dimethylformamide. Sparingly soluble in water. Anti-hypercholestrolemic compound, Anti-inflammatory and immune-modulating effects, Anticancer compound. Chemopreventive, Cytostatic. Cell growth inhibitor, Antimutagenic, Potent in vitro antagonist of FXR (farnesoid...

This nuclear receptor assay system utilizes proprietary non-human mammalian cells engineered to provide constitutive, high-level expression of human farnesoid X receptor (NR1H4), a ligand-dependent transcription factor commonly referred to as FXR. INDIGO's reporter cells include the luciferase reporter gene...

XL335 is an orally bioavailable and potent agonist of the farnesoid X receptor (FXR) with an EC50 value of 4 nM in CV-1 cells transfected with human FXR. It is selective for FXR over a panel of 15 nuclear receptors at concentrations up to 10 µM. XL335 induces expression of mouse intestinal bile acid binding protein...