64 products were found matching "K08535"!

The Liver X Receptors (LXRalpha and LXRbeta) are nuclear hormone receptors whose native ligands are oxysterols, such as 22(R)-hydroxycholesterol. The LXRs regulate the oxysterol-induced expression of cholesterol 7alpha-hydroxylase, the rate limiting enzyme of classic bile acid synthesis. T0901317 is a potent and...

The liver X receptors (LXRalpha and LXRbeta) are nuclear hormone receptors whose native ligands, oxysterols, induce the expression of genes involved in cholesterol and fatty acid metabolism. 27-hydroxy Cholesterol, a sterol 27-hydroxylase-mediated cholesterol hydroxylation product, activates LXRalpha and LXRbeta in...

24(S)-hydroxy Cholesterol is a side-chain substituted oxysterol that has important roles in cholesterol homeostasis. It is generated by the action of CYP46 on cholesterol in the brain and diffuses across the blood-brain barrier to the systemic circulation where it can modulate cell signaling, be used for further...

An LXRa and LXRß agonist, induces recruitment of an SRC-1 fragment in cell-free FRET-based assays (EC50s = 74 and 25 nM for LXRa and LXRß, respectively), induces cholesterol efflux in RAW 264.7 macrophages (EC50 = 17 nM), increases plasma levels of VLDL, LDL, and triglycerides in hamsters at 10 mg/kg twice per day...

24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain. It activates liver X receptors (LXRs) in the developing ventral midbrain to induce stem cell differentiation into dopaminergic neurons. 24(S),25-epoxy Cholesterol inhibits IL-6 production and degranulation of bone...

The liver X receptors, LXRalpha and LXRbeta, are nuclear receptors that act as ligand-dependent transcription factors. They modulate cholesterol, fatty acids, and glucose homeostasis. GW 3965 is an orally-active agonist of LXRalpha and LXRbeta, activating the human isoforms with EC50 values of 190 and 30 nM,...

This nuclear receptor assay system utilizes proprietary non-human mammalian cells engineered to provide constitutive, high-level expression of human liver X receptor beta (NR1H2), a ligand-dependent transcription factor commonly referred to as LXRbeta. INDIGO's reporter cells include the luciferase reporter gene...

GSK2033 is an antagonist of liver X receptor alpha (LXRalpha) and LXRbeta (IC50s = 0.1 and 0.398 µM, respectively) that has no agonist activity in an LXR transactivation assay. It inhibits LXR agonist-induced and basal expression of the LXR target genes ATP-binding cassette transporter 1 (ABCA1) and sterol...

BMS 779788 is a partial agonist of liver X receptor alpha (LXRalpha) and LXRbeta (Kis = 68 and 14 nM, respectively, in a radioligand binding assay). It activates LXRalpha and LXRbeta with EC50 values of 230 and 250 nM, respectively, in a transactivation assay. BMS 779788 increases expression of ATP-binding cassette...

The liver X receptors (LXRs) are nuclear receptors that act as ligand-dependent transcription factors. They modulate lipid, cholesterol, and carbohydrate metabolism and homeostasis. SR9238 is an inverse agonist of the two LXR isoforms, LXRalpha and LXRbeta (IC50s = 214 and 43 nM, respectively). It displays liver...

The liver x receptors (LXRalpha and LXRbeta) are nuclear hormone receptors whose native ligands, oxysterols, induce the expression of genes involved in cholesterol and fatty acid metabolism. 27-hydroxy Cholesterol, a sterol 27-hydroxylase-mediated cholesterol hydroxylation product, activates LXRalpha and LXRbeta in...

The liver X receptors (LXRs) are nuclear receptors that act as ligand-dependent transcription factors. They modulate lipid, cholesterol, and carbohydrate metabolism and homeostasis. SR9243 is a cell-permeable LXR inverse agonist that induces LXR-corepressor interaction at nanomolar concentrations. It reduces cancer...