33 products were found matching "K08362"!

MB-07811 is a liver-targeted prodrug form of the thyroid hormone receptor beta (TRbeta) agonist MB-07344. It is stable in extrahepatic tissues and converted to MB-07344 in the liver. MB-07811 binds to TRalpha1 and TRbeta1 with Ki values of 12.5 and 14.6 µM, respectively. Oral administration of MB-07811 reduces...

3,3',5-Triiodo-L-thyronine (T3) is a thyroid hormone. It is produced by 5'-monodeiodination of the prohormone thyroxine (T4) in various tissues, including liver and kidney. T3 is an agonist of thyroid hormone receptors TRalpha and TRbeta (Kis = 2.3 nM for both) that modulates diverse biological properties, including...

Thyroid hormone receptor antagonist (1-850) competitively blocks T3 binding to both TRalpha and TRbeta (IC50s = 1.5 µM), demonstrating ~1,000-fold lower affinity for TRalpha in intact cells compared with T3. This compound is specific, showing no effect on the activity of the related retinoic acid receptor...

Tiratricol is a metabolite of 3,3',5-triiodo-L-thyronine (Cay-16028) and an agonist of the thyroid hormone receptors TRalpha and TRbeta (EC50s = 1.81 and 4.13 nM, respectively, in reporter assays). In vivo, tiratricol (50 or 400 ng/g) stimulates cerebellar Purkinje cell dendritogenesis and cortical myelination in...

Anti-Thyroid Hormone Receptor beta antibody is directed against human TR?. Thyroid Hormone Receptor beta antibody is purified by Protein G chromatography. This antibody is specific for the human protein. Cross reactivity from other sources has not been determined. Protein function: High affinity receptor for...

MGL-3196 is an agonist of thyroid hormone receptor beta (TRbeta, EC50s = 0.21 and 3.74 µM for TRbeta and TRalpha, respectively). It also inhibits ether-a-go-go-related gene (ERG) potassium channels (IC50 = 30 µM). MGL-3196 is a liver-directed compound, with a liver to plasma ratio of 8:1 in mice with diet-induced...

3,5-Diiodo-L-thyronine (3,5-T2) is a thyroid hormone metabolite. It binds to thyroid hormone receptor alpha1 (TRalpha1), TRbeta1, and TRbeta2 (EC50s = 0.8, 0.79, and 0.1 µM, respectively, in cell-free assays). 3,5-T2 (1 pM) stimulates oxygen consumption in perfused livers isolated from rats with hypothyroidism...

L-Thyroxine is a synthetic form of the thyroid hormone thyroxine. In vivo, L-thyroxine (0.9 and 2.7 µg) inhibits synthesis and release of thyrotropin induced by thyrotropin-releasing hormone (Cay-22917) from the anterior pituitary in mice. It also reverses decreases in levels of circulating thymic serum factor (FTS)...

Sobetirome is an agonist of thyroid hormone receptor beta (TRbeta, EC50 = 7 nM in a reporter assay). It selectively binds to TRbeta over TRalpha with Kd values of 0.1 and 1.8 nM, respectively. Sobetirome (97 nmol/kg, i.p.) increases hepatic levels of the HDL receptor SR-B1 and serum levels of C4, a marker of...

Protein function: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. [The UniProt Consortium]

This nuclear receptor assay system utilizes proprietary human cells engineered to provide constitutive, high-level expression of the human thyroid hormone receptor beta (NR1A2), a ligand-dependent transcription factor commonly referred to as TRbeta. INDIGO's reporter cells include the luciferase reporter gene...

Protein function: High affinity receptor for triiodothyronine. [The UniProt Consortium]