120 products were found matching "K06068"!

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members...

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. Phospho-PKC delta (Tyr311) antibody detects PKC delta phosphorylated at tyrosine 311, encoded by the PRKCD gene. PKC delta is a member of the novel protein kinase C family of serine-threonine kinases,...

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. PKC delta/theta antibody detects protein kinase C delta and protein kinase C theta, encoded by the PRKCD and PRKCQ genes. PKC delta is also called nPKC delta, while PKC theta is known as nPKC theta....

Rottlerin was originally identified as an inhibitor of PKCdelta (IC50 = 3 µM), but can also inhibit CAM kinase III and a wide range of protein kinases, including PRAK and MAPKAP-K2 (IC50s = 1.9 and 5 µM, respectively). It can act as a direct mitochondrial uncoupler, and stimulates autophagy by targeting a signaling...

Specific protein kinase C (PKC) activator, Selective activator of PKC isoforms, like PKCtheta in T cells, Antiproliferative and proapoptotic (necrotic), Immunostimulant, Chemotherapeutic, Anticancer compound, Efficacious agent against actinic kerastosis, Antileukemic. Isolated from Euphorbia peplus L.

(-)-Indolactam V is a tumor-promoting teleocidin compound that activates protein kinase C (PKC). It binds to PKC regulatory domains of mouse skin PKCeta and rat brain PKCgamma with Ki values of 3.4 nM and 1 µM, respectively. At 1 µM, (-)-indolactam V induces differentiation of human embryonic stem cells into...

Protein function: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine...

Description: Rottlerin (NSC-56346) is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCdelta of 3-6 µM, PKCalpha,beta,gamma of 30-42 µM, PKCepsilon,eta,zeta of 80-100 µM). Rottlerin causes apoptosis via caspase 3 activation. Target: Autophagy, Apoptosis, CaMK, HIV...

Description: Sotrastaurin (AEB071) is a potent pan-PKC inhibitor with Kis of 0.95 nM for PKCalpha, 0.64 nM for PKCbetaI, 2.1 nM for PKCdelta, 3.2 nM for PKCepsilon, 1.8 nM for PKCeta, and 0.22 nM for PKCtheta. Target: PKC. Smiles: CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc2n1. References: Evenou JP, et...

Protein function: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Protein kinase C delta type, also called PKCD, is an enzyme that in humans is encoded by the PRKCD gene. The PRKCD gene encodes a member of the protein kinase C family, members of which are critical for regulation of cell survival, proliferation, and apoptosis....

Ingenol is a diterpenoid related to phorbol, derived from the milkweed plant E. peplus. It is a protein kinase C activator that displays a Ki value of 30 µM and an ED50 value of 27 µM in vitro. Most ingenol esters are tumor-promoting. However, ingenol mebutate possesses anti-tumor activity when used topically for...