117 products were found matching "K05855"!

This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and...

Recombinant human SYK, Genbank Accession # NM_003177, a.a. 359-635(end), expressed in Sf9 insect cells using an N-terminal GST tag. MW = 58 kDa. Assay conditions: SYK was incubated with a substrate (Tyr peptide 2) for 1 hr. at RT in 1X kinase buffer supplemented with ATP. Developer solution was added to reaction and...

R406 is a potent ATP-competitive inhibitor of spleen tyrosine kinase (Syk, Ki = 30 nM). Through this action, R406 blocks FcepsilonRI-dependent mast cell activation (EC50 = 43 nM) and, at 3 µM, reduces the release of IL-10, -12, and -13 by immune complex-pulsed dendritic cells. R406 is orally available and can reduce...

BAY 61-3606 is an inhibitor of spleen tyrosine kinase (Syk, Ki = 7.5 nM). It is selective for Syk over Lyn, Fyn, Src, Itk, and BTK (Kis = >4.7 µM for all). BAY 61-3606 inhibits anti-IgE-induced histamine release in isolated human mast cells sensitized with IgE (IC50 = 5.1 nM), as well as reduces anti-IgM-induced...

MNS is a beta-nitrostyrene that blocks and reverses platelet aggregation induced by such triggers as collagen, U-46619 (Cay-16450), and ADP (IC50 = 1.1, 2.1, and 4.1 µM, respectively). It reduces tyrosine phosphorylation in stimulated platelets and inhibits recombinant human Syk and Src (IC50 = 2.8 and 27.3 µM,...

Protein function: Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation,...

Synthetic. Originally isolated from Euphorbia lagascae. Wide range of tyrosine and serine/threonine protein kinase inhibitor, including Syk, p56lck, PKA, PKC, MLCK, CDPK, JNK and PI3K. Inhibits the tyrosine phosphorylation of STAT3 and STAT5. Potent apoptosis inducer. Potent anticancer compound. Suppresses NF-kB...

BIIB-057 is a potent inhibitor of the non-receptor tyrosine kinase Syk (IC50 = 1 nM). It displays at least 80-fold selectivity for Syk over other kinases. BIIB-057 blocks B cell receptor-mediated cell signaling and activation in whole blood (IC50s = 0.27 and 0.28 µM, respectively), as well as Fc? receptor 1-mediated...

Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs of FcRgamma chains and mediates downstream signaling related to platelet function and inflammation. GS-9973 is a potent Syk inhibitor (IC50 = 7.7 nM) that demonstrates...

Slightly soluble (<1mg/ml) in DMSO or ethanol. Tamatinib effectively inhibits BCR signaling in vivo, resulting in reduced proliferation and survival of the malignant B cells and significantly prolonged survival of the treated animals. Target: BCR , Kinase Group: PTK , Substrate: Tyrosine

Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs (ITAMs) of FcRgamma chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibitor is an oxindole compound that potently blocks Syk...

Description: PRT-060318 (P142-76) is a novel selective inhibitor of the Syk tyrosine kinase, as an approach to HIT treatment. Target: Syk. Smiles: Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)ncc2C(N)=O)c1. References: Reilly MP, et al. Blood. 2011, 117(7):2241-2246.