- Search results for K05094
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83 products were found matching "K05094"!
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Item number: ELK-ELK3160.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human FGFR3. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human FGFR3. Next,...
Keywords: | JTK4, FGFR3, CD333, FGFR-3, EC=2.7.10.1, Fibroblast growth factor receptor 3 |
Application: | ELISA |
Species reactivity: | human |
From 365.00€
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Item number: BPS-101818-1
Recombinant human FGFR3 (fibroblast growth factor receptor 3, also known as CD333), encompassing amino acids 23-375 corresponding to the extracellular domain of the receptor. This construct contains a C-terminal Avi-Tag(TM) followed by a His-Tag (6xHis). This protein was affinity purified. HiP(TM) indicates a high...
Keywords: | JTK4, CD333, FGFR3, FGFR-3, EC=2.7.10.1, Fibroblast growth factor receptor 3, FGFR3 (23-375-Avi-His)-(Biotin) |
Application: | Cancer therapy target, Biotin-avidin-pulldown |
Expressed in: | Human cells |
Origin: | human |
MW: | 41+glyc kD |
From 518.00€
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Item number: BPS-101819-1
Recombinant human FGFR3 (fibroblast growth factor receptor 3, also known as CD333), encompassing amino acids 23-375 corresponding to the extracellular portion of the receptor. This construct contains a C-terminal Fc domain followed by an Avi-Tag(TM). This protein has a Factor Xa cleavage site prior to the Fc domain....
Keywords: | JTK4, CD333, FGFR3, FGFR-3, EC=2.7.10.1, Fibroblast growth factor receptor 3, FGFR3 (23-375-Fc(lgG1)-Avi) |
Application: | Cancer therapy target |
Expressed in: | Human cells |
Origin: | human |
MW: | 67+glyc kD |
From 400.00€
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Item number: BPS-40212
Human FGFR3, (GenBank Accession #NM_000142) with N-terminal GST-tag, a.a 397-end, MW= 73 kDa, expressed in Sf9 cells via a baculovirus expression system.
Keywords: | JTK4, CD333, FGFR3, FGFR-3, EC=2.7.10.1, Fibroblast growth factor receptor 3, |
Application: | Enzyme kinetics, inhibitor screening, selectivity profiling |
Expressed in: | insect cells |
Origin: | human |
MW: | 73 kD |
862.00€
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Item number: Cay19157-1
BGJ398 is an orally available inhibitor of human FGFRs (IC50s = 0.9, 1.4, and 1 nM for FGFR1, FGFR2, and FGFR3, respectively). It inhibits FGFR4 and VEGFR2 with IC50 values of 60 and 180 nM, respectively, and displays comparatively little activity towards Abl, Fyn, Kit, Lck, Lyn, and Yes (IC50s = 0.3-2.5 µM). BGJ398...
Keywords: | NVP-BGJ398, Infigratinib,... |
Application: | FGFR1 / FGFR2 / FGFR3 inhibitor |
CAS | 872511-34-7 |
MW: | 560.5 D |
From 84.00€
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Item number: Cay26955-1
Roridin E is a macrocyclic trichothecene mycotoxin that has been found in M. verrucaria. It inhibits the receptor tyrosine kinases FGFR3, IGF-1R, PDGFRbeta, and TrkB (IC50s = 0.4, 0.4, 1.4, and 1 µM, respectively). Roridin E induces cytotoxicity in multiple breast cancer cell lines (IC50s = 0.02-0.05 nM) and...
Keywords: | (2'E,7'R)-2',3'-didehydro-7'-deoxo-2'-deoxy-7'-[(1R)-1-hydroxyethyl]-verrucarin A |
Application: | Macrocyclic trichothecene mycotoxin, FGFR3/IGF-1R/PDGFRbeta/TrkB inhibitor |
CAS | 16891-85-3 |
MW: | 514.6 D |
From 222.00€
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Item number: Cay13032-25
The fibroblast growth factor receptors (FGFRs) are cell surface receptors with intrinsic tyrosine kinase activity, which is necessary for receptor activation and signal propagation. PD 173074 is a potent and selective inhibitor of FGFR tyrosine kinase activity, blocking autophosphorylation of FGFR1 with an IC50...
Keywords: | N-[2-[[4-(diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)-urea |
Application: | FGFR inhibitor |
CAS | 219580-11-7 |
MW: | 523.7 D |
From 53.00€
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Item number: Cay21813-25
JNJ-42756493 is a pan-FGFR inhibitor (IC50s = 1.2, 2.5, 3, and 5.7 nM for FGFR1, -2, -3, and -4, respectively). It is selective for FGFRs over VEGFR2 (IC50 = 36.8 nM). JNJ-42756493 inhibits the proliferation of Ba/F3 cells expressing FGFR1, -3, or -4 (IC50s = 22.1, 13.2, and 25 nM, respectively). It reduces tumor...
Keywords: | Erdafitinib, N1-(3,5-dimethoxyphenyl)-N2-(1-methylethyl)-N1-[3-(1-methyl-1H-pyrazol-4-yl)-6-quinoxalinyl]-1,2-ethanediamine |
Application: | FGFR inhibitor |
CAS | 1346242-81-6 |
MW: | 446.6 D |
From 42.00€
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Item number: ARG53020.500
Protein function: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is...
Keywords: | Anti-JTK4, Anti-CD333, Anti-FGFR3, Anti-FGFR-3, EC=2.7.10.1, Anti-Fibroblast growth factor receptor 3 |
Application: | IHC (paraffin) |
Host: | Rabbit |
Species reactivity: | human |
608.00€
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Item number: G-HUFI02460.96
Application: | ELISA |
Species reactivity: | human |
641.00€
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Item number: SYN-1217-M100
Solid. Soluble in DMSO. S49076 is a novel, potent inhibitor of MET, AXL/MER and FGFR1/2/3. It can potently block cellular phosphorylation of MET, AXL and FGFRs and inhibit downstream signalling in vitro and in vivo. S49076 can inhibit the proliferation of MET- and FGFR2-dependent gastric cancer cells, block...
Keywords: | S-49076 . HCl, (Z)-3-((3-((4-(Morpholinomethyl)-1H-pyrrol-2-yl)methylene)-2-oxoindolin-5-yl)methyl)thiazolidine-2,4-dione... |
Application: | MET AXL/MER & FGFR1/2/3 inhibitor |
CAS | 1265965-19-2 |
MW: | 475,0 D |
Please request pricing for this article.
Item number: Cay17120-5
CH5183284 is a potent, selective inhibitor of the kinase activity of fibroblast growth factor receptors (FGFRs) 1, 2, and 3 (IC50s = 9.3, 7.6, and 22 nM, respectively). It less potently inhibits FGFR4 and platelet-derived growth factor receptor beta (IC50s = 290 and 560 nM, respectively) and displays IC50 values...
Keywords: | Debio 1347, [5-amino-1-(2-methyl-1H-benzimidazol-6-yl)-1H-pyrazol-4-yl]-1H-indol-2-yl-methanone |
Application: | FGFR1/2/3 inhibitor |
CAS | 1265229-25-1 |
MW: | 356.4 D |
From 66.00€
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