46 products were found matching "K05082"!

Protein function: Receptor for thrombopoietin that acts as a primary regulator of megakaryopoiesis and platelet production. May represent a regulatory molecule specific for TPO-R-dependent immune responses. [The UniProt Consortium]

The c-mpl gene encodes a member of the hematopoietic cytokine receptor superfamily. This gene was discovered through the study of a murine retrovirus which induces an acute myeloproliferative syndrome in mice.MPLV (for myeloproliferative leukemia virus) has transduced a truncated and constitutively activated form of...

Lusutrombopag is an agonist of the thrombopoietin receptor. It induces proliferation of Ba/F3 cells expressing human MPL, the gene for the thrombopoietin receptor, with an EC50 value of 84 nM but not of those expressing mouse Mpl. Lusutrombopag (0.3-10 mg/kg per day) increases the number of circulating platelets in...

Description: Eltrombopag Olamine (Eltrombopag diethanolamine salt) is an orally active small-molecule, nonpeptide thrombopoietin receptor agonist that stimulates megakaryopoiesis. It binds to and activates the transmembrane domain of the platelet thrombopoietin receptor (TPO-R or CD110), promoting the proliferation...

Eltrombopag-13C4 is intended for use as an internal standard for the quantification of eltrombopag (Cay-13247) by GC- or LC-MS. Eltrombopag is an orally bioavailable nonpeptide agonist of the thrombopoietin receptor (EC50 = 0.27 µM in a reporter assay) and an iron chelator. It increases STAT5 phosphorylation in...

Avatrombopag is an agonist of the thrombopoietin receptor. It induces proliferation of Ba/F3 cells expressing the thrombopoietin receptor (EC50 = 3.3 nM) and induces differentiation of hematopoietic progenitor cells into megakaryotes. Avatrombopag is species-specific, inducing STAT5 phosphorylation in human and...

This assay utilizes proprietary human cells that provide constitutive expression fo the Human Thrombopoietin Receptor (TPOR). TPOR, also known as MPL or CD110, is a member of the type I cytokine receptor superfamily. Thrombopoietin (TPO), the physiological activator of TPOR, is a glycoprotein that regulates...

In 1X PBS, pH 7.4, with 0.09% sodium azide. Myeloproliferative leukemia protein (MPL) is the receptor for Thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses. [UniProt] Protein function: Receptor for thrombopoietin that acts as a primary regulator of megakaryopoiesis and...

Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 26-491aa. Protein Length: Extracellular Domain. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: QDVSLLASDS EPLKCFSRTF EDLTCFWDEE EAAPSGTYQL LYAYPREKPR ACPLSSQSMP HFGTRYVCQF PDQEEVRLFF PLHLWVKNVF LNQTRTQRVL FVDSVGLPAP PSIIKAMGGS QPGELQISWE...

Organism: Homo sapiens (Human). Source: Yeast. Expression Region: 26-491aa. Protein Length: Extracellular Domain. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: QDVSLLASDS EPLKCFSRTF EDLTCFWDEE EAAPSGTYQL LYAYPREKPR ACPLSSQSMP HFGTRYVCQF PDQEEVRLFF PLHLWVKNVF LNQTRTQRVL FVDSVGLPAP PSIIKAMGGS QPGELQISWE...

Recombinant Human c-MPL with C-terminal human Fc tag. c-MPL(Gln26-Ala490) hFc(Glu99-Ala330), Protein function: Receptor for thrombopoietin that acts as a primary regulator of megakaryopoiesis and platelet production. May represent a regulatory molecule specific for TPO-R-dependent immune responses. [The UniProt...

Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...