37 products were found matching "K05038"!

A non-opioid analgesic, an inhibitor of GlyT2 (IC50 = 0.86 µM), antagonist of 5-HT2A and P2X3 (IC50s = 1.3 and 0.87 µM, respectively), reduces mechanical allodynia in a rat model of neuropathic pain induced by spinal nerve ligation (ED50 = 80 mg/kg). SMILES: COC1=CC(C(NCC2(N(C)C)CCOCC2)=O)=CC(OC)=C1OCCCC.Cl. InChi...

This gene encodes a sodium- and chloride-dependent glycine neurotransmitter transporter. This integral membrane glycoprotein is responsible for the clearance of extracellular glycine during glycine-mediated neurotransmission. This protein is found in glycinergic axons and maintains a high presynaptic pool of...

Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA.

Oleoyl-L-carnitine is a long-chain acylcarnitine and an inhibitor of glycine transporter 2 (GlyT2, IC50 = 340 nM). It is selective for GlyT2 over GlyT1 (IC50 = >10,000 nM). Plasma levels of oleoyl-L-carnitine are increased in patients with chronic kidney disease or end-stage renal disease receiving incident...

Bitopertin is an inhibitor of glycine transporter 1 (GlyT1, IC50 = 0.03 µM). It is selective for GlyT1 over GlyT2 (IC50 = >30 µM) as well as a panel of 107 receptors, transporters, and enzymes at 10 µM. Bitopertin (0.1 µM) increases long-term potentiation in rat hippocampal CA1 slices. It reverses hyperlocomotion...

Sarcosine is an intermediate in the biosynthesis of glycine from choline. It is a selective inhibitor of glycine transporter 1 (GlyT1) with IC50 values of 91 and greater than 1,000 µM for GlyT1 and GlyT2, respectively, in HEK293 cells expressing the human transporters. Sarcosine levels are increased in prostate...

Oleoyl-D-lysine is an inhibitor of glycine transporter 2a (GlyT2a). It selectively inhibits GlyT2a (IC50 = 48.3 nM) over GlyT1b (IC50 = >3,000 nM) in Xenopus oocytes expressing the human transporters. Oleoyl-D-lysine (30 mg/kg, i.p.) reduces allodynia in a nerve ligation rat model of neuropathic pain.Formal Name:...

The amino acid glycine acts as an inhibitory neurotransmitter in the central nervous system. The protein encoded by this gene is one of two transporters that stop glycine signaling by removing it from the synaptic cleft. Protein function: Terminates the action of glycine by its high affinity sodium- dependent...

The amino acid glycine acts as an inhibitory neurotransmitter in the central nervous system. The protein encoded by this gene is one of two transporters that stop glycine signaling by removing it from the synaptic cleft. Protein function: Terminates the action of glycine by its high affinity sodium- dependent...

ALX 5407 is an inhibitor of glycine transporter 1 (GlyT1, IC50 = 3 nM). It is selective for GlyT1 over GlyT2 (IC50 = >10 µM), as well as over NMDA receptors and the inhibitory glycine receptor at 100 µM. ALX 5407 (10 mg/kg) increases prefrontal cortical levels of glycine in rats. It also reverses MK-801-induced...

Protein function: Terminates the action of glycine by its high affinity sodium- dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as...

Description: GlyT1 Inhibitor 1 is a potent and selective GlyT1 inhibitor [IC50: 38 nM for rGlyT1] exhibiting antipsychotic activity. Target: Others. Smiles: CC(C)Oc1ccc(cc1C(=O)N1Cc2cn(nc2C1)-c1ccnc(C)c1)C#N. References: Santora VJ, et al. Design and Synthesis of Novel and Selective Glycine Transporter-1 (GlyT1)...