18 products were found matching "K04957"!

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human HCN4. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human HCN4. Next,...

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated (HCN) channels contribute to native pacemaker currents in heart and neurons and modulate cardiac and neuronal excitability. Certain HCN channels also accentuate neuropathic pain. ZD 7288 is a potent blocker of HCN channels that inhibits HCN4 more...

Anti-HCN4 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with HCN4 from Human, Rat, and Mouse based on 100% homology with the immunizing sequence. No cross-reactivity against other HCNs. Cross-reactivity with HCN4 from other sources has not been determined....

Ivabradine is a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker that blocks the mixed sodium/potassium inward funny current (If) in HEK293 cells expressing mouse HCN1, human HCN2, and human HCN4 (EC50s = 4.5, 4.52, and 4.28 µM, respectively). In vivo, ivabradine (10 mg/kg per day) reduces...

DK-AH 269 blocks hyperpolarization-activated cyclic nucleotide-gated (HCN) channels (IC50 = 0.62 µM in mouse sinoatrial node cells). DK-AH 269 slows heart rate by decreasing the spontaneous firing rate of the sinoatrial node in the heart. Using telemetric ECG recordings in mice, it reduced heart rate in a...

Ivabradine-d3 is intended for use as an internal standard for the quantification of ivabradine (Cay-15868) by GC- or LC-MS. Ivabradine is a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker that blocks the mixed sodium/potassium inward funny current (If) in HEK293 cells expressing mouse HCN1,...

HCN4 Antibody is a IgG polyclonal antibody from Assay Genie with reactivity against Human, Mouse, Rat and for use in ELISA, IHC applications. HCN4 Antibody is a high quality polyclonal antibody for research use only.. Protein function: Hyperpolarization-activated ion channel with very slow activation and...

HCN4 Antibody is a IgG polyclonal antibody from Assay Genie with reactivity against Human, Mouse, Rat and for use in ELISA, IHC applications. HCN4 Antibody is a high quality polyclonal antibody for research use only.. Protein function: Hyperpolarization-activated ion channel with very slow activation and...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 is a protein that in humans is encoded by the HCN4 gene. This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein...

Protein function: Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. May contribute to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat. May contribute to the native pacemaker currents in...

This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have...