89 products were found matching "K04850"!

Verapamil is the prototypical blocker of L-type calcium channels that produces excitation-contraction uncoupling in cardiac muscle by preventing the slow-inward current of calcium ions. Verapamil can also block calcium fluxes in vascular smooth muscle. It has both peripheral and coronary vasodilator effects (IC50 =...

Nifedipine is a dihydropyridine L-type calcium channel blocker that reduces the amplitude of spontaneous contractions in isolated rabbit ileum when used at a concentration of 1 µM. Nifedipine (1 µM) reduces TGF-beta-induced calcium oscillations in human fibroblasts and prevents impairment of lung function in a mouse...

Nimodipine is an inhibitor of L-type voltage-gated calcium (CaV) channels. It is selective for CaV1.2 over CaV1.3 channels (IC50s = 0.139 and 2.7 µM, respectively), as well as R-, N-, and P/Q-type Cav channels at 10 µM. Nimodipine (0.72-24 nM) inhibits contractions induced by potassium, but not norepinephrine, in...

Isradipine is a selective L-type calcium channel blocker with long-acting antihypertensive activity. It demonstrates an EC50 value of 1.4 nM for relaxation of depolarization-induced contractions of rabbit aorta and an EC25 value of 0.45 nM for reduction in rate of spontaneously beating guinea pig right atria. By...

Nisoldipine is a calcium channel inhibitor. It binds to calcium channels in isolated rat ventricular membranes (Kd = 0.04 nM) and inhibits calcium uptake by smooth muscle cells. Nisoldipine inhibits acetylcholine-induced contraction of isolated rabbit coronary arteries (IC50 = 0.03 nM). In vivo, nisoldipine (3...

Felodipine is an inhibitor of L-type calcium channels. It induces relaxation of precontracted isolated porcine coronary artery segments (EC50 = 0.15 nM), which highly express L-type calcium channels. Felodipine is selective for L-type calcium channels over N-, R-, and P/Q-type channels at 10 µM, as well as the...

FPL 64176 is a nondihydropyridine that activates L-type Ca2+ channels with an EC50 value of 16 nM. It prolongs action potential duration and increases contractility in guinea pig atria preparations with an EC50 value of 49 nM.Formal Name: 2,5-dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylic acid, methyl...

Amlodipine-d4 is intended for use as an internal standard for the quantification of amlodipine (Cay-14838) by GC- or LC-MS. Amlodipine is a dihydropyridine L-type calcium channel blocker that selectively inhibits calcium influx in cardiac and vascular smooth muscle. Acting as a vasodilator, amlodipine reduces blood...

(S)-(-)-BAY-K-8644 is an activator of voltage-sensitive L-type calcium channels. It demonstrates vasoconstrictive and positive inotropic effects in vivo as well as behavioral effects, including deficits to motor function. When combined with BIX01294 (Cay-13124), (S)-(-)-BAY-K-8644 can enable reprogramming of mouse...

Bepridil is a dihydropyridine that has anti-anginal and anti-arrhythmic actions by blocking calcium channels in heart and smooth muscle. It is recognized as a non-selective channel blocker, altering myocardial Ca2+, Na+, and K+ currents. For example, it blocks voltage-gated Ca2+ (Cav3.2) and K+ (hERG and KCNQ4)...

Calcium channel blocker.

Manidipine is a dihydropyridine L- and T-type calcium channel blocker. It blocks recombinant rabbit L-type (alpha1Calpha2/deltabeta1a) and human T-type (alpha1H) calcium channels expressed in Xenopus oocytes and native L-type channels in dissociated guinea pig cardiac ventricular cells (IC50 = 2.6 nM). Manidipine...