24 products were found matching "K04842"!

Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: SCN10A. Antigen Species: Human

Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: SCN10A. Antigen Species: Human

Suzetrigine is an inhibitor of voltage-gated sodium channel 1.8 (Nav1.8, IC50 = 0.7 nM for the human channel). It is selective for Nav1.8 over a panel of eight additional voltage-gated sodium channels (IC50s = >10,000 nM for all).Formal Name:...

Nav1.8 is a tetrodotoxin-resistant (TTX-R) sodium channel with high activation threshold and slow inactivating kinetics that is highly expressed in small-diameter sensory neurons and has been implicated in signaling various types of pain. A-803467 is a sodium channel blocker with high-affinity and selectivity for...

Lamotrigine is an anticonvulsant. It inhibits voltage-gated sodium channels (Nav) in HEK293 cells expressing recombinant human Nav1.2, Nav1.5, or Nav1.8 (IC50s = 10, 62, and 96 µM, respectively), as well as high voltage-activated calcium currents in isolated rat cortical neurons (IC50 = 12.3 µM), an effect that can...

Ambroxol is an expectorant and active metabolite of bromhexine. It decreases short-circuit currents in electrically stimulated isolated canine tracheal epithelial cells when applied submucosally (IC50 = 60 nM). It inhibits the voltage-gated sodium channel Nav1.2 in isolated dorsal root neurons (IC50 = 110 µM for the...

(-)-Ropivacaine-d7 is intended for use as an internal standard for the quantification of (-)-ropivacaine (Cay-21422) by GC- or LC-MS. (-)-Ropivacaine is a potent and reversible blocker of sodium channels in nerve fibers. In vivo, (-)-ropivacaine induces complete impairment of proprioception, motor function, and...

Protein function: Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium- selective channel through which sodium ions may pass in...

Stable recombinant HEK293 cell line expressing tetracycline-inducible human Nav1.8 (Genbank #NP_006505.2) fused to Green Fluorescent Protein (GFP) [Ex. ~395 nm, 475 nm, em ~510 nm] and the human sodium channel beta2 subunit (Genbank #NM_004588, SCN2B). Nav1.8 is also known as tetrodotoxin-resistant voltage-gated...

Anti-NAV1.8 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with NAV1.8 from human, mouse, and rat based on 100% homology with the immunizing sequence. No cross reactivity against other Nav channels. Cross-reactivity with NAV1.8 from other sources has not been...

PF-01247324 is a blocker of the tetrodotoxin-resistant (TTX-R) sodium channel Nav1.8 (IC50 = 0.19 µM for human Nav1.8). It is selective for Nav1.8 over Nav1.1, Nav1.2, Nav1.5, and Nav1.7 channels (IC50s = 13, 12.8, 9, and 19 µM, respectively) as well as ether-a-go-go (ERG) potassium channels (IC50 = 30 µM)....

Raxatrigine is an inhibitor of voltage-gated sodium channels (Nav, IC50s = 22, 13, 23, 10, 84, 15, 32, and 6 µM for Nav1.1-Nav1.8 channels in a FLIPR membrane potential assay using HEK293 cells). Its activity is state-dependent at the Nav1.7 channel, with a nine-fold increase in potency for the open/inactivated...