27 products were found matching "K04841"!

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GX-674
GX-674

Item number: Cay39677-10

GX-674 is a state-dependent inhibitor of voltage-gated sodium channel 1.7 (Nav1.7). It selectively inhibits Nav1.7 in HEK293 cells in a patch-clamp assay at -40 mV over -120 mV, voltages that correspond to steady-state inactivation and the resting closed state of the channel (IC50s = 0.1 and 240 nM, respectively)....
Keywords: 4-[2-(2-amino-1H-benzimidazol-6-yl)-4-chlorophenoxy]-2,5-difluoro-N-1,2,4-thiadiazol-5-yl-benzenesulfonamide
Application: State-dependent Nav1.7 inhibitor
CAS 1432913-36-4
MW: 534.9 D
From 62.00€ *
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Carbamazepine
Carbamazepine

Item number: Cay15422-5

Carbamazepine is an inhibitor of sodium channels. It preferentially inhibits inactivated voltage-gated sodium channel Nav1.7 and Nav1.3 (IC50s = 406 and 900 µM, respectively) over resting (closed) Nav1.7 and Nav1.3 channels in whole-cell patch-clamp assays using HEK293 cells (IC50s = 1,584 and 2,464 µM,...
Keywords: CBZ, NSC 169864, 5H-dibenz[b,f]azepine-5-carboxamide
Application: Voltage-gated sodium channel blocker
CAS 298-46-4
MW: 236.3 D
From 35.00€ *
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Lacosamide-d3
Lacosamide-d3

Item number: Cay25426-500

Lacosamide-d3 (Cay-25426) is an analytical reference standard intended for use as an internal standard for the quantification of lacosamide by GC- or LC-MS. Lacosamide is categorized as an anticonvulsant. Formulations containing lacosamide have induced euphoria, auditory and visual hallucinations, and psychosis in...
Keywords: 2R-(acetylamino)-3-(methoxy-d3)-N-(phenylmethyl)-propanamide
Application: Analytical reference standard, GC-MS, LC-MS internal standard, Quantification, Anticonvulsant
CAS 1217689-95-6
MW: 253.3 D
From 245.00€ *
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Bupivacaine
Bupivacaine

Item number: Cay16618-500

Bupivacaine is a sodium channel blocker and local anesthetic. It inhibits sodium currents in rat dorsal horn neurons in a concentration-dependent manner and inhibits synaptic transmission in rat sympathetic ganglia, increasing the firing threshold when used at a concentration of 200 nM. Bupivacaine (10 µM) blocks...
Keywords: 1-butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide
Application: Sodium influx blocker
CAS 38396-39-3
MW: 288.4 D
From 43.00€ *
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NaV1.7 - HEK293 recombinant human stable cell line (2x10(6) cells)
NaV1.7 - HEK293 recombinant human stable cell line...

Item number: BPS-60507

Nav1.7 (Genbank # Q15858) is present at the endings of pain-sensing nerves, the nociceptors, close to region where the impulse is initiated. The Nav1.7 channel produces a rapidly activating and inactivating current which is sensitive to level of tetrodotoxin. Knockout mice that lack Nav1.7 in nociceptors showed...
Keywords: PN1, NENA, hNE-Na, Peripheral sodium channel 1, Neuroendocrine sodium channel, Sodium channel protein type 9 subunit...
Application: Drug screening, functional assays
13,502.00€ *
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Anti-Nav1.7 Na+ Channel, clone S68-6
Anti-Nav1.7 Na+ Channel, clone S68-6

Item number: ARG56140.50

Protein function: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical...
Keywords: Anti-PN1, Anti-NENA, Anti-hNE-Na, Anti-Peripheral sodium channel 1, Anti-Neuroendocrine sodium channel, Anti-Sodium...
Application: IHC (paraffin), WB
Host: Mouse
Species reactivity: hamster, human, mouse, rat
628.00€ *
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Anti-NAV1.7, clone S68-6
Anti-NAV1.7, clone S68-6

Item number: 200-301-G21

Anti-NAV1.7 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with NAV1.7 from Human, Rat, and Mouse based on 100% homology with the immunizing sequence. No cross-reactivity against other Nav channels. Cross-reactivity with NAV1.7 from other sources has not been...
Keywords: Anti-PN1, Anti-NENA, Anti-SCN9A, Anti-hNE-Na, Anti-Peripheral sodium channel 1, Anti-Neuroendocrine sodium channel,...
Application: IHC, IFM, IP, WB
Host: Mouse
Species reactivity: human, mouse, rat
698.00€ *
Review
Anti-SCN9A
Anti-SCN9A

Item number: E-AB-16052.120

This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder. Protein function: Mediates the voltage-dependent...
Keywords: Anti-PN1, Anti-NENA, Anti-hNE-Na, Anti-Peripheral sodium channel 1, Anti-Neuroendocrine sodium channel, Anti-Sodium...
Application: IHC, ELISA
Host: Rabbit
Species reactivity: human
From 71.00€ *
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Benzonatate
Benzonatate

Item number: Cay23936-1

Benzonatate is a reversible voltage-gated sodium channel blocker. It blocks Nav1.7 currents in a concentration- and voltage-dependent manner (IC50s = 5.9 and 1.4 µM at holding potentials of -100 and -70 mV, respectively) and inhibits action potential firing in catecholamine A differentiated (CAD) cells. Benzonatate...
Keywords: 4-(butylamino)-benzoic acid, 3,6,9,12,15,18,21,24,27-nonaoxaoctacos-1-yl ester
Application: Reversible voltage-gated sodium channel blocker
CAS 104-31-4
MW: 603.8 D
From 60.00€ *
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Anti-SCN9A
Anti-SCN9A

Item number: E-AB-12861.120

This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder. Protein function: Mediates the voltage-dependent...
Keywords: Anti-PN1, Anti-NENA, Anti-hNE-Na, Anti-Peripheral sodium channel 1, Anti-Neuroendocrine sodium channel, Anti-Sodium...
Application: IHC, ELISA
Host: Rabbit
Species reactivity: human
From 71.00€ *
Review
PF-05089771 (tosylate)
PF-05089771 (tosylate)

Item number: Cay24449-10

PF-05089771 is a voltage-gated sodium channel 1.7 (Nav1.7) blocker (IC50s = 11, 16, 33, and 20 nM for 5N11S, 5A11L, 5A11S, and 5A11L Nav1.7 splice variants, respectively). It is selective for Nav1.7 over Nav1.1-1.6 and 1.8 channels (IC50s = 0.11-25 µM), L-type calcium, and KvLQT and hERG potassium channels (IC50s =...
Keywords: 4-[2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-4-thiazolyl-4-benzenesulfonamide,...
Application: Nav1.7 blocker
CAS 1430806-04-4
MW: 672.6 D
From 131.00€ *
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Tolperisone (hydrochloride)
Tolperisone (hydrochloride)

Item number: Cay26078-5

Tolperisone is a piperidine that acts as an inhibitor of voltage-gated sodium channels with an IC50 value of 198 µM, for inhibition of peak sodium currents evoked by step depolarizations in dorsal root ganglion (DRG) neurons, in vitro. Tolperisone acts as an antispastic agent that attenuates monosynaptic,...
Keywords: N-553, 2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanone, monohydrochloride
Application: Voltage-gated sodium channel inhibitor, muscle relaxant
CAS 3644-61-9
MW: 281.8 D
From 245.00€ *
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