18 products were found matching "K04840"!
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Raxatrigine (hydrochloride)
Item number: Cay23490-5
Raxatrigine is an inhibitor of voltage-gated sodium channels (Nav, IC50s = 22, 13, 23, 10, 84, 15, 32, and 6 µM for Nav1.1-Nav1.8 channels in a FLIPR membrane potential assay using HEK293 cells). Its activity is state-dependent at the Nav1.7 channel, with a nine-fold increase in potency for the open/inactivated...
| Keywords: | GSK1014802A, (2S)-5R-[4-[(2-fluorophenyl)methoxy]phenyl]-2-pyrrolidinecarboxamide, monohydrochloride |
| Application: | Voltage-gated sodium channel inhibitor |
| CAS | 934240-31-0 |
| MW: | 350.8 D |
From 58.00€
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Bupivacaine
Item number: Cay16618-25
Bupivacaine is a sodium channel blocker and local anesthetic. It inhibits sodium currents in rat dorsal horn neurons in a concentration-dependent manner and inhibits synaptic transmission in rat sympathetic ganglia, increasing the firing threshold when used at a concentration of 200 nM. Bupivacaine (10 µM) blocks...
| Keywords: | 1-butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide |
| Application: | Sodium influx blocker |
| CAS | 38396-39-3 |
| MW: | 288.4 D |
From 51.00€
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Zandatrigine
Item number: TGM-T39630-100mg
Description: Zandatrigine (NBI-921352) is a sodium channel protein type 8 subunit alpha blocker, suitable for studies on epilepsy treatment and nervous system pathologies. Target: Sodium Channel. Smiles: CN([C@H]1CCN(Cc2ccccc2)C1)c1cc(F)c(cc1C)S(=O)(=O)Nc1cscn1. References: Jean-Christophe ANDREZ, et al....
| Keywords: | XEN901, NBI-921352 |
| Application: | Targets voltage-gated sodium channel type VIII alpha (SCN8A, NAV1.6) |
| CAS | 2154406-04-7 |
| MW: | 460.59 D |
From 112.00€
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SCN8A (human), recombinant protein
Item number: ABS-PP-4579-L.100
Protein function: Mediates the voltage-dependent sodium ion permeability of excitable membranes (PubMed:29726066). Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their...
| Keywords: | Sodium channel protein type 8 subunit alpha, Sodium channel protein type VIII subunit alpha, Voltage-gated sodium channel... |
| Expressed in: | E.coli |
| Origin: | human |
| MW: | 17 kD |
From 115.00€
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Scn8A, Mouse sodium channel, voltage-gated, type VIII,...
Item number: VMPS-5710
Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....
| Keywords: | Scn8a, Nbna1, Sodium channel protein type 8 subunit alpha, Sodium channel protein type VIII subunit alpha, Voltage-gated... |
| Application: | RNA quantification |
45.00€
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SCN8A, Human sodium channel, voltage gated, type VIII,...
Item number: VHPS-8158
Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....
| Keywords: | MED, SCN8A, Sodium channel protein type 8 subunit alpha, Sodium channel protein type VIII subunit alpha, Voltage-gated... |
| Application: | RNA quantification |
45.00€
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Scn8A, Rat sodium channel, voltage gated, type VIII,...
Item number: VRPS-5433
Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....
| Keywords: | PN4, Scn8a, NaCh6, Sodium channel 6, Peripheral nerve protein type 4, Sodium channel protein type 8 subunit alpha, Sodium... |
| Application: | RNA quantification |
54.00€
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SCN8A PrEST Antigen
Item number: ATA-APrEST94669.100
Protein function: Mediates the voltage-dependent sodium ion permeability of excitable membranes (PubMed:29726066). Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their...
| Keywords: | MED, SCN8A, Sodium channel protein type 8 subunit alpha, Sodium channel protein type VIII subunit alpha, Voltage-gated... |
| Application: | Control antigen |
| Expressed in: | E.coli |
| Origin: | human |
264.00€
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SCN8A PrEST Antigen
Item number: ATA-APrEST95188.100
Protein function: Mediates the voltage-dependent sodium ion permeability of excitable membranes (PubMed:29726066). Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their...
| Keywords: | MED, SCN8A, Sodium channel protein type 8 subunit alpha, Sodium channel protein type VIII subunit alpha, Voltage-gated... |
| Application: | Control antigen |
| Expressed in: | E.coli |
| Origin: | human |
264.00€
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Anti-SCN8A
Item number: ATA-HPA043937.100
Protein function: Mediates the voltage-dependent sodium ion permeability of excitable membranes (PubMed:29726066). Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their...
| Keywords: | Anti-MED, Anti-SCN8A, Anti-Sodium channel protein type 8 subunit alpha, Anti-Sodium channel protein type VIII subunit... |
| Application: | ICC |
| Host: | Rabbit |
| Species reactivity: | human |
From 369.00€
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Anti-SCN8A
Item number: ATA-HPA073590.100
Protein function: Mediates the voltage-dependent sodium ion permeability of excitable membranes (PubMed:29726066). Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their...
| Keywords: | Anti-MED, Anti-SCN8A, Anti-Sodium channel protein type 8 subunit alpha, Anti-Sodium channel protein type VIII subunit... |
| Application: | ICC |
| Host: | Rabbit |
| Species reactivity: | human |
From 369.00€
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Anti-SCN8A
Item number: ELK-ES11792.100
This gene encodes a member of the sodium channel alpha subunit gene family. The encoded protein forms the ion pore region of the voltage-gated sodium channel. This protein is essential for the rapid membrane depolarization that occurs during the formation of the action potential in excitable neurons. Mutations in...
| Keywords: | Anti-MED, Anti-SCN8A, Anti-Sodium channel protein type 8 subunit alpha, Anti-Sodium channel protein type VIII subunit... |
| Application: | WB, ELISA |
| Host: | Rabbit |
| Species reactivity: | human, mouse, rat |
From 173.00€
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