64 products were found matching "K04733"!

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. IRAK4 antibody detects Interleukin-1 receptor-associated kinase 4, a serine/threonine kinase that mediates innate immune signaling through Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs). Encoded by the IRAK4 gene on chromosome...

In 1X PBS, pH 7.4, with 0.09% sodium azide. Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells,...

Edecesertib is an inhibitor of IL-1 receptor-associated kinase 4 (IRAK4, IC50 = 0. nM). It is selective for IRAK4 over a panel of 484 additional kinases at 1,000 nM. Edecesertib inhibits toll-like receptor 7 (TLR7) agonist-induced IFN-alpha production in isolated human whole blood (IC50 = 124 nM). Dietary...

KT474 is a proteolysis-targeting chimera (PROTAC) that drives the degradation of IL-1 receptor-associated kinase 4 (IRAK4). It induces the degradation of IRAK4 in primary mouse and rat splenocytes and isolated dog, monkey, and human peripheral blood mononuclear cells (PBMCs) with half-maximal degradation...

Solulibility: DMSO: Sparingly Soluble: 1-10 mg/ml: Ethanol: Slightly Soluble: 0.1-1 mg/ml.

IL-1 receptor-associated kinase 1 (IRAK1) (360-380) is a peptide substrate of IRAK4. It has been used in competition assays to identify inhibitors of IRAK4.. Solulibility: DMSO: Soluble: =10 mg/ml: PBS (pH 7.2): Sparingly Soluble: 1-10 mg/ml.

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Interleukin-1 receptor-associated kinase 4, also called REN64, is an IRAK family protein kinase involved in signaling innate immune responses from Toll-like receptors. It also supports signaling from T-cell receptors. Scott(2002) mapped the gene to chromosome 12...

Interleukin-1 receptor-associated kinases (IRAKs) are important mediators in the signal transduction of Toll/IL-1 receptor (TIR) family members. Dysregulation of TIR signaling, typified by increased NF-kappaB activity, results in the development of some cancers and other diseases, making the development of IRAK...

PF-06650833 is an inhibitor of IL-1 receptor-associated kinase 4 (IRAK4, IC50 = 0.2 nM). It is selective for IRAK4 over a panel of 268 kinases at 200 nM but also inhibits IRAK1, MAP kinase-interacting serine/threonine protein kinase 2 (MNK2), leucine-rich repeat kinase 2 (LRRK2), CDC-like kinase 4 (Clk4), and casein...

Protein function: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor- signaling complex upon TLR activation to form the Myddosome...

Active human IRAK4 (GenBank Accession No. NM_001114182) (aminoacids 2-end) with N-terminal GST tag, MW= 77.5 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

The toll-like receptor (TLR) family in mammals comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an interleukin-1 (IL-1) receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor...