108 products were found matching "K04725"!

Rabbit Polyclonal XIAP Antibody against Human X-linked inhibitor of apoptosis. Validated for Western Blot. Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Interspecies information: Highest antigen sequence indentity to the following orthologs: ENSMUSG00000025860: 86%,...

Human XIAP (GenBank Accession No. NM_001167), amino-acids 2-end, with N-terminal DDDDK tag (FLAG), MW= 57 kDa, expressed in a Baculovirus infected Sf9 cell expression system. Useful in conjunction with E1 and E2 for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Birinapant is a bivalent mimetic of the Diablo homolog known as second mitochondria-derived activator of caspase (Smac). It is an antagonist of cellular inhibitor of apoptosis 1 (cIAP1, or BIRC2), cIAP2 (BIRC3), and XIAP (BIRC4), binding each at nanomolar concentrations. Birinapant causes rapid cIAP1 degradation,...

SM-164 is a cell-permeable bivalent mimetic of Smac and an inhibitor of X-linked inhibitor of apoptosis (XIAP). It binds to BIR2 and BIR3 domain-containing XIAP with an IC50 value of 1.39 nM and interacts with both domains. SM-164 inhibits growth (IC50 = 1 nM), as well as activates caspase-3 and caspase-9, and...

Embelin is a benzoquinone that has been found in E. ribes and has diverse biological activities. It inhibits viral replication of the influenza A subtype H1N1 and the influenza B subtype Victoria-like in MDCK cells (IC50s = 0.3 and 0.2 µM, respectively). It is also an inhibitor of X-linked inhibitor of apoptosis...

Human x-linked inhibitor of apoptosis (XIAP), also known as IAP-like protein, API3, X-linked IAP, and BIRC4, amino-acids 120 ? 356 containing Bir2 and Bir3 domains (GenBank Accession No. NM_001167) with N-terminal His-tag, MW = 28.3 kDa, expressed in an E. coli expression system.

Inhibitor of apoptosis proteins (IAPs), which block various signaling pathways leading to apoptotic cell death, are commonly over-expressed in cancer cells. GDC-0152 is a potent inhibitor of specific IAPs that binds baculoviral IAP repeat (BIR) domains (Kis = 28, 14, 17, and 43 nM for XIAP BIR3, NL-IAP BIR, BIRC2...

MX69 is an inhibitor of the interaction between the ubiquitin ligase MDM2 protein and XIAP mRNA. It binds to the RING domain of MDM2 (Kd = 2.34 µM) and decreases the levels of MDM2 and XIAP in a concentration-dependent manner without affecting the levels of Bcl-2, cIAP-1, and cIAP-2. It induces autoubiquitination...

Protein function: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the...

Protein function: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the...

Potent anticancer agent that blocks DNA synthesis. Induces apoptosis via p53-dependent and -independent mechanisms. Inhibits X-linked inhibitor of apoptosis protein (XIAP) expression and activates caspase-3. In certain glioma cell lines, sensitizes cells to TNF-alpha-induced apoptosis.

Human x-linked inhibitor of apoptosis (XIAP) Bir3 domain, also known as IAP-like protein, API3, X-linked IAP, and BIRC4, amino-acids 241 ? 356 (GenBank Accession No. NM_001167) with N-terminal His-tag, MW = 14.2 kDa, expressed in an E. coli expression system.