36 products were found matching "K04715"!

Description: NVP-231 is a potent, specific and reversible CerK inhibitor(IC50=12±2 nM) that competitively inhibits ceramide binding to CerK. Target: Apoptosis, ERK. Smiles: O=C(Nc1nc2ccc(NC(=O)C34CC5CC(CC(C5)C3)C4)cc2s1)c1ccccc1. References: Graf C, et al.Mol Pharmacol. 2008 Oct,74(4):925-32.

Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: CERK. Antigen Species: Human

Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: CERK. Antigen Species: Human

NVP-231 is a potent and reversible inhibitor of ceramide kinase (IC50 = 12 nM). It is selective for ceramide kinase over SPHK1, SPHK2, DAGKa, PI3Ka, PI4Kb, VPS34, GCS, SMS-1, and CERT (IC50s = >5 mM). NVP-231 inhibits formation of ceramide-1-phosphate (C1P, IC50 = 10 nM) and cell death in ceramide kinase...

Human ceramide kinase (CERK) (GenBank Accession No. NM_022766), 1-537(end) with C-terminal Flag tag, MW= 60 kDa, expressed in baculovirus expression system. A unit of ceramide kinase activity is defined as the amount of enzyme required to produce 1 pmole of ceramide-1-phosphate/min at 37°C. Assay condition: 20 mM...

Substrate for ceramide kinase (CERK), optimized for use with beta-Octylglucoside mixed micellar assay. Assay conditions: Prepare a fresh 1:4 mixture of ceramide and ceramide buffer. Sonicate the mixture 3 times for 2 min. using a bath sonicator to make a 2.5 X solution (250 µM ceramide). A final ceramide...

Substrate for ceramide kinase (CERK), optimized for use with beta-Octylglucoside mixed micellar assay. Assay conditions: Prepare a fresh 1:4 mixture of ceramide and ceramide buffer. Sonicate the mixture 3 times for 2 min. using a bath sonicator to make a 2.5 X solution (250 µM ceramide). A final ceramide...

Mouse CERK, also known as ceramide kinase, GenBank Accession No. NM_00113486, 1-531 (end) with C-terminal Flag tag, MW= 61 kDa, expressed in baculovirus expression system.

Rat CERK, also known as ceramide kinase, GenBank Accession No. NM_00113486, 1-531 (end) with C-terminal Flag tag, MW= 61 kDa, expressed in baculovirus expression system.

CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation. Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts...

CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation. Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts...