29 products were found matching "K04710"!

Fumonisin B1 (FB1) is a mycotoxin that has been found in F. moniliforme. It inhibits ceramide synthase (IC50 = 0.1 µM for the rat liver enzyme). FB1 induces DNA fragmentation and apoptosis in CV-1 cells when used at concentrations of 5 and 25 µM, respectively. It is cytotoxic to primary rat hepatocytes and induces...

C14 Ceramide is an endogenous ceramide generated by ceramide synthase 6. During nutrient-deprivation-induced necroptosis in MEF cells, C14 ceramide levels increase in a time-dependent manner. C14 ceramide plasma levels were reduced in obese patients with or without diabetes following a 12-week supervised exercise...

740 Y-P is a synthetic phosphopeptide activator of PI3K. It contains amino acids from the Antennapedia protein, which acts as a cellular internalization sequence, followed by a sequence from PDGFR that is recognized by the SH2 domain of PI3K. 740 Y-P (15 µM) increases phosphorylation of PI3K, mammalian target of...

C10 ceramide is an endogenous, bioactive sphingolipid produced by ceramide synthase. C10 ceramide inhibits growth of wild-type and MDR1 gene-transfected MDA435/LCC6 human breast cancer cells with IC50 values of 44.1 and 46 µM, respectively. It also inhibits the growth of J774 murine macrophages in a dose-dependent...

C16 Ceramide-d7 is intended for use as an internal standard for the quantification of C16 ceramide (d18:1/16:0) by GC- or LC-MS. C16 Ceramide is a sphingolipid. It incorporates into the mitochondrial outer membrane and forms channels that increase its permeability. C16 Ceramide levels are increased by PPMP or MAPP...

P053 is an inhibitor of ceramide synthase 1 (CerS1, IC50s = 0.54 and 0.46 µM for human and mouse CerS1, respectively). It is selective for CerS1 over CerS2, CerS4, CerS5, and CerS6 (IC50s = 28.6, 17.2, 7.2, and 11.4 µM, respectively). P053 decreases the production of C18 ceramide (Cay-19556) from dihydrosphingosine...

Description: 740 Y-P (740YPDGFR) is a potent and cell-permeable activator of PI3K. Target: Autophagy, PI3K. Smiles:...

Protein function: May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner. [The UniProt Consortium]

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: LAG1, CerS1 antibody, Ceramide synthase 1 Protein function: May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the...

A mycotoxin isolated from Fusarium moniliforme. This compound induces apoptosis in rat and monkey kidney cells.

Fumonisin is a group of toxins (B1 or FB1, B2 or FB2, which are equally toxic, and B3 or FB3, which is relatively nontoxic) which are produced by fungi (Fusarium moniliforme and F. proliferatum) that causes equine leukoencephalomalacia, a disease of the central nervous system of equines and is associated with the...

A Mycotoxin isolated from Fusarium moniliforme. This compound is an inhibitor of the enzyme spingosine acyltransferase.