24 products were found matching "K04608"!

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(S)-MCPG
(S)-MCPG

Item number: Cay21450-25

(S)-MCPG is an antagonist of metabotropic glutamate receptors (mGluRs) and the active component of (±)-MCPG, which is selective for Group I and Group II mGluRs. (S)-MCPG inhibits motoneuron depolarization induced by 1-amino-1,3-dicarboxycyclopentane (ACPD) in neonatal rat spinal cord in vitro and ACPD-induced...
Keywords: (+)-MCPG, (+)-alpha-methyl-4-Carboxyphenylglycine, (S)-alpha-methyl-4-Carboxyphenylglycine,...
Application: Non-selective group I/group II metabotropic glutamate receptor antagonist
CAS 150145-89-4
MW: 209.2 D
From 89.00€ *
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MMPIP (hydrochloride)
MMPIP (hydrochloride)

Item number: Cay18862-1

MMPIP is a reversible allosteric antagonist of the metabotropic glutamate receptor 7 (mGluR7) that blocks agonist-induced calcium mobilization (IC50 = 26 nM). It does not affect other mGlu receptors. The modulation of mGluR7 by MMPIP is context dependent, in that it is not observed in all known mGluR7 signaling...
Keywords: 6-(4-methoxyphenyl)-5-methyl-3-(4-pyridinyl)-isoxazolo[4,5-c]pyridin-4(5H)-one, monohydrochloride
Application: mGluR7 antagonist
CAS 1215566-78-1
MW: 369.8 D
From 92.00€ *
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DCPG
DCPG

Item number: Cay22072-1

DCPG is a selective agonist of the class III metabotropic glutamate receptor 8 (mGluR8), with an EC50 value of 31 nM for inhibiting forskolin-stimulated cAMP formation in AV12-664 cells expressing human mGluR8. It is selective for mGluR8 over other mGluRs (EC50s = >3.5 µM for mGluR1-7). In vitro, DCPG (1 µM)...
Keywords: (S)-3,4-DCPG, 4-[(S)-aminocarboxymethyl]-1,2-benzenedicarboxylic acid
Application: mGluR8a agonist
CAS 201730-11-2
MW: 239.2 D
From 43.00€ *
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ACPT-I
ACPT-I

Item number: Cay78010-10

ACPT-I is an agonist of the group III metabotropic glutamate receptors (mGluRs) mGluR4a and mGluR8 (EC50s = 7.2 and 8.2 µM, respectively) that has no effect on mGluR1a or mGluR2. It has diverse biological activity, including neuroprotective, anticonvulsant, and anxiolytic-like effects. ACPT-I (1-200 µM) reduces cell...
Keywords: (4beta)--amino-1alpha,2alpha,4-cyclopentanetricarboxylic acid
Application: mGluR4a / mGluR8 agonist
CAS 194918-76-8
MW: 217.2 D
From 60.00€ *
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O-Phospho-L-Serine
O-Phospho-L-Serine

Item number: Cay16151-10

O-Phospho-L-Serine is an agonist of the group III metabotropic glutamate receptors mGluR4a and mGluR6 (EC50s = 2-5 µM). It mimics the phosphatidylserine head group and has been shown to inhibit the proliferation of microglia and to enhance neuronal differentiation of progenitor cells.Formal Name:...
Keywords: Dexfosfoserine, L-Serine-O-Phosphate, L-SOP, O-phosphono-L-serine
Application: mGluR4 / mGluR6 agonist
CAS 407-41-0
MW: 185.1 D
From 34.00€ *
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XAP044
XAP044

Item number: Cay19095-1

XAP044 is an antagonist of the metabotropic glutamate (mGlu) receptor 7 (mGluR7), inhibiting lateral amygdala long term potentiation in brain slices from wild-type mice with an IC50 value of 88 nM. This effect is absent in mGluR7-deficient mice. XAP044 demonstrates good brain penetrance, producing wide spectrum...
Keywords: 7-hydroxy-3-(4-iodophenoxy)-4H-1-benzopyran-4-one
Application: mGluR7 antagonist
CAS 196928-50-4
MW: 380.1 D
From 43.00€ *
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(±)-trans-ACPD
(±)-trans-ACPD

Item number: Cay28849-5

(±)-trans-ACPD is an agonist of metabotropic glutamate receptors (mGluRs, EC50s = 15, 2, 40, 23, and 82 µM for mGluR1, -2, -3, -5, and -6, respectively, in CHO cells expressing recombinant receptors). It also activates mGluR4 in baby hamster kidney cells with an EC50 value of approximately 800 µM. (±)-trans-ACPD...
Keywords: (1R,3S)-1-aminocyclopentane-1,3-dicarboxylic acid
Application: mGluR agonist
CAS 67684-64-4
MW: 173.2 D
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CPPG
CPPG

Item number: Cay34362-5

CPPG is an antagonist of group II and group III metabotropic glutamate receptors (mGluRs). It reverses inhibition of forskolin-induced cAMP accumulation induced by the mGluR group II selective agonist L-CCG-1 or the mGluR group III-selective agonist L-AP4 (Cay-14538) in rat cerebrocortical slices (IC50s = 46.2 and...
Keywords: alpha-Cyclopropyl-4-phosphonophenylglycine, alpha-amino-alpha-cyclopropyl-4-phosphono-benzeneacetic acid
Application: Group II and group III mGluR antagonist
CAS 183364-82-1
MW: 271.2 D
From 50.00€ *
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Anti-GRM6
Anti-GRM6

Item number: ATA-HPA014511.100

Protein function: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Signaling...
Keywords: Anti-GRM6, Anti-mGluR6, Anti-GPRC1F, Anti-Metabotropic glutamate receptor 6
Application: IHC
Host: Rabbit
Species reactivity: human
From 335.00€ *
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Anti-mGluR-6
Anti-mGluR-6

Item number: ELK-ES5678.100

glutamate metabotropic receptor 6(GRM6) Homo sapiens L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in...
Keywords: Anti-GRM6, Anti-GPRC1F, Anti-mGluR6, Anti-Metabotropic glutamate receptor 6, mGluR-6 rabbit pAb
Application: WB, IHC, IF, ELISA
Host: Rabbit
Species reactivity: human, rat, mouse,
169.00€ * From 152.10€ *
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GRM6, Human glutamate receptor, metabotropic 6, Real Time PCR Primer Set
GRM6, Human glutamate receptor, metabotropic 6, Real Time...

Item number: VHPS-3873

Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....
Keywords: GRM6, mGluR6, GPRC1F, Metabotropic glutamate receptor 6
Application: RNA quantification
43.00€ *
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GRM7, Human glutamate receptor, metabotropic 7, Real Time PCR Primer Set
GRM7, Human glutamate receptor, metabotropic 7, Real Time...

Item number: VHPS-3874

Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....
Keywords: GRM7, mGluR7, GPRC1G, Metabotropic glutamate receptor 7
Application: RNA quantification
43.00€ *
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