31 products were found matching "K04578"!

A CRF1 antagonist (Ki = 1.9 nM), selective for CRF1 over CRF2alpha and a panel of 125 receptors, transporters, ion channels, and enzymes at 10 µM, inhibits CRF-induced cAMP production in Y79 cells (IC50 = 3 nM) and CRF-induced ACTH secretion in AtT-20 cells at 3, 30, and 100 nM, prevents restraint stress-induced...

Corticotropin-releasing hormone (CRH) secreted from the hypothalamus is the major regulator of pituitary corticotropin-release and consequent glucocorticoid secretion. Antalarmin is a selective, nonpeptide antagonist of the CRH receptor 1 (Ki = 1 nM) that, consequently, reduces the release of corticotropin in...

Protein function: G-protein coupled receptor for CRH (corticotropin- releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase....

Protein function: G-protein coupled receptor for CRH (corticotropin- releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase....

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Corticotropin releasing hormone receptor 1, CRFR1 Protein function: G-protein coupled receptor for CRH (corticotropin- releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN....

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Corticotropin releasing hormone receptor 1, CRHR1 Protein function: G-protein coupled receptor for CRH (corticotropin- releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN....

CP 154,526 is an antagonist of corticotropin-releasing factor receptor 1 (CRF1, Ki = 2.7 nM). It is selective for CRF1 over CRF2 (Ki = >10 µM). CP 154,526 inhibits CRF-induced increases in adrenocorticotropic hormone (ACTH) levels in rat plasma with an ID50 value of 10 mg/kg. It increases the time spent in the open...

CP 376,395 is an antagonist of corticotropin-releasing factor (CRF) receptor 1 (CRF1, IC50 = 5.1 nM). It inhibits adenylate cyclase activity stimulated by ovine CRF in rat cerebral cortex and at human CRF1 receptors. CP 376,395 (17.8 mg/kg) inhibits CRF-induced increases in the acoustic startle response in rats. It...

Pexacerfont is an antagonist of corticotropin-releasing factor receptor 1 (CRF1, IC50 = 6.1 nM for the human receptor). It is selective for CRF1 in IMR-32 cells (mean IC50 = 10.6 nM) over CFR2beta receptors endogenously expressed in pig choroid plexus membranes (IC50 = >1,000 nM) in radioligand binding assays and...

Corticotropin-releasing hormone, also known as corticotropin-releasing factor (CRF) or corticoliberin, is a peptide hormone and neurotransmitter involved in the stress response. It is secreted from the hypothalamus and is the major regulator of pituitary corticotropin-release and consequent glucocorticoid secretion....

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat CRHR1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat CRHR1. Next,...