45 products were found matching "K04577"!
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MK-3207
Item number: Cay42490-1
MK-3207 is an antagonist of the calcitonin gene-related peptide (CGRP) receptor (Ki = 22 pM for the recombinant human receptor). It is selective for the CGRP receptor over adrenomedullin receptor 1 (AM1) and AM2, calcitonin (CT) receptor, and amylin 3 receptor (AMY3, Kis = 16. 0. 1. and 0. µM, respectively) but does...
| Keywords: | 8R-(3,5-difluorophenyl)-10-oxo-N-[(2R)-1,1',2',3-tetrahydro-2'-oxospiro[2H-indene-2,3'-[3H]pyrrolo[2,3-b]pyridin]-5-yl]-6,... |
| Application: | CGRP receptor antagonist |
| CAS | 957118-49-9 |
| MW: | 557.6 D |
From 58.00€
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Ubrogepant
Item number: TGM-T17194-100mg
Description: Ubrogepant (MK-1602) is a calcitonin gene-related peptide receptor antagonist used in acute migraine treatment studies. Target: CGRP Receptor. Smiles: C[C@@H]1[C@@H](C[C@H](NC(=O)c2cnc3C[C@]4(Cc3c2)C(=O)Nc2ncccc42)C(=O)N1CC(F)(F)F)c1ccccc1. References: Li CC, et al. Population PK Analyses of Ubrogepant...
| Keywords: | MK-1602 |
| Application: | Targets calcitonin receptor-like (CALCRL) |
| CAS | 1374248-77-7 |
| MW: | 549.54 D |
From 154.00€
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Atogepant
Item number: TGM-T26682-100mg
Description: Atogepant is an antagonist of calcitonin gene-related peptide receptor. Target: Others. Smiles: [H][C@]1(C[C@H](NC(=O)c2cnc3C[C@]4(Cc3c2)C(=O)Nc2ncccc42)C(=O)N(CC(F)(F)F)[C@@H]1C)c1c(F)ccc(F)c1F
| Keywords: | MK 8031, MK-8031, MK8031. Atogepant |
| Application: | Targets calcitonin receptor-like (CALCRL) |
| CAS | 1374248-81-3 |
| MW: | 603.52 D |
From 1,791.00€
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Vazegepant
Item number: TGM-T38734-10mg
Description: Vazegepant (Zavegepant) is an orally available and selective antagonist of the calcitonin gene-related peptide CGRP receptor for pain relief and may be used in the study of migraine. Target: CGRP Receptor. Smiles:...
| Keywords: | BMS-742413, BHV-3500, Zavegepant |
| Application: | Targets calcitonin receptor-like (CALCRL) |
| CAS | 1337918-83-8 |
| MW: | 638.8 D |
From 105.00€
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Rimegepant
Item number: TGM-T4610-10mg
Description: Rimegepant (BMS 927711) is a highly potent, oral calcitonin gene-related peptide (CGRP) receptor antagonist with a Ki value of 0.027 nM. Target: CGRP Receptor. Smiles: N[C@H]1[C@@H](CC[C@@H](OC(=O)N2CCC(CC2)n2c3cccnc3[nH]c2=O)c2ncccc12)c1cccc(F)c1F. References: Pan KS, et al. Antagonism of CGRP...
| Keywords: | BMS-927711, BMS 927711, BMS927711, BHV-3000 |
| Application: | Targets calcitonin receptor-like (CALCRL) |
| CAS | 1289023-67-1 |
| MW: | 534.56 D |
From 49.00€
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Rimegepant sulfate hydrate
Item number: TGM-T70837-100mg
Description: Rimegepant, also known as BMS-927711 and BHV-3000, is a potent, selective, competitive, and orally active calcitonin gene-related peptide (CGRP) antagonist in clinical trials for treating migraines. Rimegepant has shown in vivo efficacy without vasoconstriction effect. BMS-927711 is superior to placebo...
| Application: | Targets calcitonin receptor-like (CALCRL) |
| CAS | 1374024-48-2 |
| MW: | 1221.2526 D |
From 2,873.00€
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Vazegepant hydrochloride
Item number: TGM-T8682-100mg
Description: Vazegepant hydrochloride (Vazegepant HCl) is the first intranasal gepant for the acute treatment of migraine and has announced a positive phase II/III study. Target: CGRP Receptor. Smiles: Cl.CN1CCC(CC1)N1CCN(CC1)C(=O)[C@@H](Cc1cc(C)c2[nH]ncc2c1)NC(=O)N1CCC(CC1)c1cc2ccccc2[nH]c1=O. References:...
| Keywords: | Vazegepant HCl |
| Application: | Targets calcitonin receptor-like (CALCRL) |
| CAS | 1414976-20-7 |
| MW: | 675.3 D |
From 108.00€
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Human CGRPR Protein, hFc Tag
Item number: DIM-PME101375.10
Recombinant human CGRPR Protein with C-terminal human Fc tag. CGRPR(Glu23-Asn140) hFc(Glu99-Ala330), Protein function: Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3. Receptor for adrenomedullin together with RAMP2 (PubMed:22102369,...
| Keywords: | CRLR, CALCRL, LMPHM8 |
| Expressed in: | Human cells |
| Origin: | human |
| CAS | 12 |
| MW: | 39.9 kD |
From 108.00€
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Human CGRPR Protein, mFc Tag
Item number: DIM-PME101376.10
Recombinant human CGRPR Protein with C-terminal mouse Fc tag. CGRPR(Glu23-Asn140) mFc(Pro99-Lys330), Protein function: Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3. Receptor for adrenomedullin together with RAMP2 (PubMed:22102369,...
| Keywords: | CRLR, CALCRL, LMPHM8 |
| Expressed in: | Human cells |
| Origin: | human |
| CAS | 12 |
| MW: | 40.0 kD |
From 108.00€
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Human CGRPR and RAMP1 Heterodimer Protein, hFc Tag and...
Item number: DIM-PME101404.10
Recombinant human CGRPR protein with C-terminal human Fc tag and human RAMP1 protein with C-terminal mouse Fc tag. CGRPR(Glu23-Asn140) hFc(Glu99-Ala330) and RAMP1(Cys27-Ser117) mFc(Pro99-Lys330), Protein function: Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin...
| Keywords: | CRLR, CGRPR, LMPHM8 and RAMP1 |
| Expressed in: | Human cells |
| Origin: | human |
| CAS | 12 |
| MW: | 39.9/ kD |
From 138.00€
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CGRPR-RAMP1 (human) full length protein-synthetic nanodisc
Item number: DIM-FLP100145.10
Discover a breakthrough in membrane protein research and drug development with DIMA Biotech's Synthetic Nanodiscs. Traditional methods struggle with challenges in obtaining water-soluble and bioactive forms of multi-transmembrane proteins. Our innovative polymer-based Nanodisc platform offers a game-changing...
| Keywords: | CGRPR, CALCRL, CGRP type 1 receptor, Calcitonin receptor-like receptor, Calcitonin gene-related peptide type 1 receptor,... |
| Application: | Full length transmembrane protein, FA, ELISA, screening, immunization, cell-based assays, crystallization |
| Expressed in: | Human cells |
| Origin: | human |
| MW: | 53.0 kD |
From 1,291.00€
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CGRPR-RAMP1 (human) full length protein-MNP
Item number: DIM-FLP200145.100
Plasma membrane-coated nanoparticles (MNPs) have been used in various applications, including delivery of therapeutic agents and induction of immune responses et al. Unlike the conventional strategies, MNPs directly leverage intact and natural functions of cell membranes, and show high biocompatibility, specificity,...
| Keywords: | CGRPR, CALCRL, CGRP type 1 receptor, Calcitonin receptor-like receptor, Calcitonin gene-related peptide type 1 receptor,... |
| Application: | Full length transmembrane protein, high biocompatib., ELISA, screening, immunization, cell-based assays |
| Expressed in: | Human cells |
| Origin: | human |
| MW: | 53.0 kD |
From 1,721.00€
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