65 products were found matching "K04556"!

Description: PRKN Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 55.6 kDa and the accession number is O60260.

The precise function of this gene is unknown, however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson...

Anti-PARK2 antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. PARK2 antibody is human specific. Protein function: Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2,...

Anti-Parkin pS101 antibody is directed against human Parkin protein. The antibody was affinity purified from monospecific antiserum by immunoaffinity purification and is specific for the phophorylated protein. Immunolabeling of the parkin band is absent in parkin S101 mutants. Reactivity is expected from the...

Anti-Parkin pS378 antibody is directed against human Parkin protein. The antibody was affinity purified from monospecific antiserum by immunoaffinity purification and is specific for the phophorylated protein. Immunolabeling of the parkin band is absent in parkin S378 mutants. This antibody is directed against human...

South Bay Bio's Parkin TR-FRET Ubiquitin Kit provides a fast and sensitive method monitoring ubiquitin conjugation onto both wild-type Parkin and a more active mutant W403A in solution, resulting from an enzymatic ubiquitin cascade without the need of running and staining an SDS gel. The kit enables continuous...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Parkin is a RING domain-containing E3 ubiquitin ligase involved in proteasome-dependent degradation of proteins. It is mapped to 6q26. This gene is important for mitochondrial quality control by lysosome-dependent degradation of damaged mitochondria through...

In 1X PBS, pH 7.4, with 0.09% sodium azide. Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to...

In 1X PBS, pH 7.4, with 0.09% sodium azide. Parkin possibly plays a role in the regulation of neuron death. Limits the production of reactive oxygen species (ROS). Regulates cyclin-E during neuronal apoptosis. In collaboration with CHPF isoform 2, may enhance cell viability and protect cells from oxidative stress....

Protein function: Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPT5, TOMM20, USP30, ZNF746 and AIMP2 (PubMed:10973942, PubMed:10888878,...

Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. 'E3 ubiquitin-protein ligase parkin,' also called 'Parkinson disease protein 2,' is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this...

Protein. Human Parkin (Accession Nr. O60260) is fused at the N-terminus to a His-tag. Source: Sf9 cells. Liquid. In 50mM Tris-HCl pH 8.0, 200mM sodium chloride, 10% glycerol, 5mM TCEP. Purity: >95% (SDS-PAGE). Parkin (Parkinson juvenile disease protein 2) is a ~52kDa E3 Ligase enzyme protein, encoded by the PARK2...