- Search results for K04514
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62 products were found matching "K04514"!
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Item number: Cay39163-1
GSK25 is an inhibitor of Rho-associated kinase 1 (ROCK1, IC50 = 7 nM for the human kinase). It is selective for ROCK1 over p90 ribosomal S6 kinase 1 (RSK1) and p70 ribosomal S6 kinase (p70S6K, IC50s = 398 and 1,000 nM, respectively) and is greater than 100-fold selective over a panel of 31 additional kinases. GSK25...
Keywords: | 4-(4-chloro-2-fluorophenyl)-2-(2-chloro-4-pyridinyl)-N-(6-fluoro-1H-indazol-5-yl)-1,4-dihydro-6-methyl-5-pyrimidinecarboxa... |
Application: | ROCK1 inhibitor |
CAS | 874119-56-9 |
MW: | 513.3 D |
From 82.00€
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Item number: ELK-ELK0699.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human Rock-1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human Rock-1....
Keywords: | ROCK1, ROCK-I, p160ROCK, p160 ROCK-1, Rho-associated protein kinase 1, Renal carcinoma antigen NY-REN-35, Rho-associated,... |
Application: | ELISA |
Species reactivity: | human |
From 365.00€
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Item number: AG-CR1-3564-M010
Potent, cell permeable, selective and ATP-competitive Rho-associated protein kinases inhibitor, including p160ROCK, ROCK-II and PRK2 inhibitor. Tumor cell invasion and metastasis suppressor. Smooth muscle relaxant. Decreases liver fibrosis by hepatic stellate cell growth inhibition. Antinociceptive. Blocks...
Keywords: | Y-27632 - 2HCL, (R)-(+)-trans-4-(1-Aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide dihydrochloride |
Application: | ROCK kinase inhibitor |
CAS | 129830-38-2 |
MW: | 320.2 D |
From 55.00€
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Item number: LKT-Y1000.1
Y27632 is a selective inhibitor of Rho-associated protein kinase (ROCK), Y27632 binds to the catalytic site of ROCK, preventing binding of Ras-related GTPase Rho A, which is involved in actin cytoskeleton reorganization, cell adhesion, and cell migration. Y27632 inhibits downstream endothelin and TGF- -related...
Application: | ROCK inhibitor |
CAS | 129830-38-2 |
MW: | 320.26 D |
From 121.00€
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Item number: Cay10007653-1
Rho-associated kinase (ROCK), activated by GTP-linked Rho, phosphorylates targets that are involved in cytoskeletal remodeling, smooth muscle contraction, and neuronal development. H-1152 is a potent, specific, ATP-competitive, and cell permeable inhibitor of ROCK (Ki = 1.6 nM). It is a more potent inhibitor of ROCK...
Keywords: | 5-[[(2S)-hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]-4-methyl-isoquinoline, dihydrochloride |
Application: | ROCK inhibition |
CAS | 451462-58-1 |
MW: | 392.3 D |
From 48.00€
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Item number: LKT-F0275.100
A potent Rho-kinase inhibitor and vasodilator. Since it was discovered, it has been used for the treatment of cerebral vasospasm, which is often due to subarachnoid hemorrhage, as well as to improve the cognitive decline seen in stroke victims. It has been found to be effective for the treatment of pulmonary...
Application: | ROCK inhibitor |
CAS | 105628-07-7 |
From 216.00€
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Item number: NSJ-RQ7415
0.5mg/ml if reconstituted with 0.2ml sterile DI water. This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and...
Keywords: | Anti-ROCK1, Anti-ROCK-I, Anti-p160ROCK, Anti-p160 ROCK-1, Anti-Rho-associated protein kinase 1, Anti-Renal carcinoma... |
Application: | WB, FC, Direct ELISA |
Host: | Rabbit |
Species reactivity: | human, monkey, mouse, rat |
755.00€
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Item number: Cay14245-1
Rho-associated kinase (ROCK) is a serine-threonine kinase known to play an important role in Rho-mediated cytoskeleton remodeling and contractile force generation. Down-regulation of ROCK signaling has been shown to enable the cell-adhesion interactions necessary for maintaining human embryonic stem cell survival...
Keywords: | Tzv, N-(phenylmethyl)-2-(4-pyrimidinylamino)-4-thiazolecarboxamide |
Application: | Cell-permeable ROCK inhibitor |
CAS | 1226056-71-8 |
MW: | 311.4 D |
From 54.00€
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Item number: SYN-1221-M001
Solid. Soluble in DMSO. H-1152 is a potent, specific, ATP-competitive and cell permeable ROCK inhibitor, with an IC50 of 12nM for ROCKII. H-1152 poorly inhibits PKA, PKC and myosin light chain kinase. Rho kinase (ROCK) activated by GTP-linked Rho phosphorylates targets that are involved in cytoskeletal remodelling,...
Keywords: | (S)-4-Methyl-5-((2-methyl-1,4-diazepan-1-yl)sulfonyl)isoquinoline dihydrochloride, H1152 |
Application: | Cell-permeable ROCK inhibitor |
CAS | 871543-07-6 |
MW: | 392,3 D |
From 106.00€
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Item number: LC-Y-5301_10mg
Solubility: Soluble in DMSO at 160 mg/mL, soluble in ethanol at 12 mg/mL with warming, soluble in water at 90 mg/mL, buffers, serum, or other additives may increase or decrease the aqueous solubility. Y-27632 is a novel and specific Rho-associated coiled-coil forming protein kinase (ROCK) inhibitor. Narumiya, S., et...
Keywords: | Y27, 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-trans-cyclohexanecarboxamide, dihydrochloride |
Application: | ROCK inhibitor |
CAS | 129830-38-2 |
MW: | 320,26 D |
From 80.00€
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Item number: Cay13687-1
Two Rho-associated kinases (ROCK), ROCK1 and ROCK2, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. CAY10622 is a potent, ureidobenzamide...
Keywords: | 3-[[[[[4-(aminocarbonyl)phenyl]amino]carbonyl]amino]methyl]-N-(1,2,3,4-tetrahydro-7-isoquinolinyl)-benzamide |
Application: | Rock kinase inhibitor |
CAS | 1038549-25-5 |
MW: | 443.5 D |
From 84.00€
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Item number: Cay16278-10
RKI-1447 is an inhibitor of the Rho-associated kinases ROCK1 and 2 (IC50s = 14.5 and 6.2 nM, respectively) that functions by binding to the ATP binding site of the kinase. In cancer cells, RKI-1447 at a concentration of 100 nM has been found to suppress the activation of ROCK substrates myosin light chain (MLC)-2...
Keywords: | N-[(3-hydroxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl]-urea |
Application: | ROCK inhibitor |
CAS | 1342278-01-6 |
MW: | 326.4 D |
From 82.00€
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