70 products were found matching "K04505"!

gamma-Secretase is a multi-subunit aspartyl protease that cleaves amyloid precursor protein (APP) and many other type 1 transmembrane proteins, including Notch, E-cadherin, and ErbB4. The proteolysis of APP by secretases produces beta amyloid (Abeta), a 39- to 42-amino acid peptide which forms the amyloid plaques...

Description: DAPT (LY-374973) is a gamma-secretase inhibitor that inhibits total Abeta and Abeta42 (IC50=115/200 nM) and is orally active. DAPT is also a Notch inhibitor. DAPT induces cell differentiation, autophagy and apoptosis. Target: Apoptosis, Autophagy, Gamma-secretase, Beta Amyloid. Smiles:...

gamma-Secretase is a protease complex that cleaves single-pass transmembrane proteins, such as Notch receptors and beta-amyloid precursor protein (APP), within the transmembrane domain. MK-0752 is a potent, reversible inhibitor of gamma-secretase, reducing the cleavage of APP to Abeta40 in human neuroblastoma...

gamma-Secretase inhibitor.

PF-3084014 is a gamma-secretase inhibitor (IC50s = 6.2 and 1.2 nM in an enzyme assay and in whole cells, respectively). It inhibits gamma-secretase activity without inducing Notch-related toxicity (EC50s = 1,300-3,000 nM for B cells in fetal thymic organ cultures). It reduces the level of amyloid-beta (1-40)...

White to off-white powder. Soluble in DMSO. Cell permeable, highly potent inhibitor of gamma-secretase (IC50 = 0.06 nM).

Anti-Presenilin1 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with Presenilin1 from other sources has not been determined. Protein function: Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the...

gamma-Secretase inhibitor.

GHS-R1a agonist, gamma-secretase inhibitor.

gamma-Secretase inhibitor.

ELISA Type: Sandwich. Sensitivity: 0.188ng/mL. Range: 0.313--20ng/mL. Protein function: Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein) (PubMed:15274632,...

Protein function: Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein) (PubMed:15274632, PubMed:10545183, PubMed:10593990, PubMed:10206644, PubMed:10899933,...