92 products were found matching "K04426"!

Selonsertib is an inhibitor of apoptosis signal-regulating kinase 1 (ASK1, IC50 = 5.01 nM). It decreases apoptosis and stellate cell activation in an in vitro 3D-human liver microtissue model of non-alcoholic steatohepatitis (NASH) induced by palmitic acid (Cay-10006627) when used at a concentration of 1 µM....

Apoptosis signal-regulating kinase 1 (ASK1) is the ubiquitously expressed mitogen-activated protein kinase kinase kinase 5 involved in a wide range of biological functions that are dependent on cell survival or death. NQDI-1 is a specific inhibitor of ASK1 (IC50 = 3 µM, Ki = 500 nM) that demonstrates potent...

ASK1 inhibitor 10 is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1, IC50 = 14 nM). It is selective for ASK1 over ASK2 (IC50 = 510 nM) as well as MEKK1, TAK-1, IKKbeta, ERK1, JNK1, p38alpha, GSK3beta, PKCtheta, and B-RAF (IC50s = >10,000 nM for all). It inhibits streptozotocin-induced...

GS-444217 is an inhibitor of apoptosis signal-regulating kinase 1 (ASK1, IC50 = 2.87 nM). It is selective for ASK1 over 442 additional kinases at 1 µM. GS-444217 (0.001-10 µM) inhibits phosphorylation of the ASK1 substrates MAP kinase kinase 3 (MKK3), MKK6, and MKK4, as well as their downstream substrates p38 MAPK...

Protein function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival....

Protein function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival....

Active recombinant human ASK1 (649-946) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The gene accession number is NM_005923.

Protein function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival....

Anti-ASK1 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with ASK1 from other sources has not been determined. Protein function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an...

Anti-ASK1 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with ASK1 from other sources has not been determined. Protein function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an...