- Search results for K04415
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33 products were found matching "K04415"!
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Item number: Cay19710-1
Tpl2 kinase inhibitor is an inhibitor of tumor progression locus 2 (Tpl2, IC50 = 0.05 µM). It is selective for Tpl2 over MEK, p38 MAPK, Src, MK2, and PKC (IC50s = >40, 180, >400, 110, and >400 µM, respectively). Tpl2 kinase inhibitor inhibits LPS-induced TNF-alpha production in isolated human monocytes and whole...
Keywords: | c-Cot Kinase Inhibitor, MAP3K8 Kinase Inhibitor, Tumor Progression Locus 2 Kinase Inhibitor,... |
Application: | c-Cot (MAP3K8) inhibitor |
CAS | 871307-18-5 |
MW: | 404.8 D |
From 77.00€
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Item number: Cay34059-1
Tpl2 kinase inhibitor is an inhibitor of tumor progression locus 2 (Tpl2, IC50 = 0.05 µM). It is selective for Tpl2 over MEK, p38 MAPK, Src, MK2, and PKC (IC50s = >40, 180, >400, 110, and >400 µM, respectively). Tpl2 kinase inhibitor inhibits LPS-induced TNF-alpha production in isolated human monocytes and whole...
Keywords: | c-Cot Kinase Inhibitor, MAP3K8 Kinase Inhibitor, Tumor Progression Locus 2 Kinase Inhibitor,... |
Application: | MAP3K8/COT/Tpl2 inhibitor |
MW: | 404.8 D |
From 77.00€
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Item number: BPS-40050
Human Cot/Tpl2 (GenBank Accession No. NM_005204), (a.a. 30-397), with N-terminal GST-His-tag, MW= 72 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
Keywords: | COT, TPL-2, MAP3K8, EC=2.7.11.25, Proto-oncogene c-Cot, Tumor progression locus 2, Cancer Osaka thyroid oncogene,... |
Application: | Enzyme kinetics, inhibitor screening, selectivity profiling |
Expressed in: | insect cells |
Origin: | human |
MW: | 72 kD |
525.00€
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Item number: BPS-41050
Mouse, recombinant, N-terminal His-GST-tag Description: Mouse Cot kinase (MAP3K8) GenBank Accession No. NM_007746, a.a. 30-397, with N-terminal His-GST-tag, expressed in a Baculovirus infected Sf9 cell expression system. The theoretical MW is 70 kDa. Specific Activity: 8.5 pmole/min/mg
Keywords: | Cot, TPL-2, Map3k8, EC=2.7.11.25, Proto-oncogene c-Cot, Tumor progression locus 2, Cancer Osaka thyroid oncogene,... |
Application: | Enzyme kinetics |
Expressed in: | Baculovirus |
Origin: | mouse |
MW: | 70 kD |
525.00€
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Item number: ARG58418.100
Protein function: Required for lipopolysaccharide (LPS)-induced, TLR4- mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF- alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG...
Keywords: | Anti-COT, Anti-TPL-2, Anti-MAP3K8, EC=2.7.11.25, Anti-Proto-oncogene c-Cot, Anti-Tumor progression locus 2, Anti-Cancer... |
Application: | WB |
Host: | Rabbit |
Species reactivity: | human, mouse |
624.00€
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Item number: ARG58432.50
Protein function: Required for lipopolysaccharide (LPS)-induced, TLR4- mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF- alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG...
Keywords: | Anti-COT, Anti-TPL-2, Anti-MAP3K8, EC=2.7.11.25, Anti-Proto-oncogene c-Cot, Anti-Tumor progression locus 2, Anti-Cancer... |
Application: | IHC (paraffin), WB |
Host: | Rabbit |
Species reactivity: | human, rat |
520.00€
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Item number: G-CBCAB01238.96
MAP3K8 (Phospho-Thr290) Colorimetric Cell-Based ELISA Kit Protein function: Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the...
Keywords: | COT, TPL-2, MAP3K8, EC=2.7.11.25, Proto-oncogene c-Cot, Tumor progression locus 2, Cancer Osaka thyroid oncogene,... |
Application: | In-cell ELISA |
641.00€
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Item number: G-CAB15623.100
WB 1:500 - 1:2000. Protein function: Required for lipopolysaccharide (LPS)-induced, TLR4- mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF- alpha (TNF) during immune responses. Involved in the regulation of T-helper cell...
Keywords: | Anti-COT, Anti-TPL-2, Anti-MAP3K8, EC=2.7.11.25, Anti-Proto-oncogene c-Cot, Anti-Tumor progression locus 2, Anti-Cancer... |
Application: | WB |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
From 352.00€
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Item number: ATA-HPA017962.100
Protein function: Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression...
Keywords: | Anti-COT, Anti-TPL-2, Anti-MAP3K8, EC=2.7.11.25, Anti-Proto-oncogene c-Cot, Anti-Tumor progression locus 2, Anti-Cancer... |
Application: | ICC, IHC, WB |
Host: | Rabbit |
Species reactivity: | human |
From 300.00€
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Item number: E-AB-91223.120
This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This...
Keywords: | COT, TPL-2, MAP3K8, EC=2.7.11.25, Proto-oncogene c-Cot, Tumor progression locus 2, Cancer Osaka thyroid oncogene,... |
Application: | WB |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
From 198.00€
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-10 %
Discount Promotion
Item number: ELK-ES1516.100
This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This...
Keywords: | Anti-phospho-COT, Anti-phospho-TPL-2, Anti-phospho-MAP3K8, EC=2.7.11.25, Anti-phospho-Proto-oncogene c-Cot,... |
Application: | WB, IHC, IF, ELISA |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
169.00€
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From 152.10€
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-10 %
Discount Promotion
Item number: ELK-ES2031.100
This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This...
Keywords: | Anti-COT, Anti-TPL-2, Anti-MAP3K8, EC=2.7.11.25, Anti-Proto-oncogene c-Cot, Anti-Tumor progression locus 2, Anti-Cancer... |
Application: | WB, IHC, IF, ELISA |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
169.00€
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From 152.10€
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