33 products were found matching "K04414"!
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NG 25 (hydrochloride hydrate)
Item number: Cay27579-1
NG 25 is a type II kinase inhibitor that inhibits MAP4K2 and TAK1 (IC50s = 21.7 and 149 nM, respectively). It also inhibits the Src family kinases Src and LYN (IC50s = 113 and 12.9 nM, respectively) and Abl family kinases (IC50s = 75.2 nM), as well as CSK, FER, and p38alpha (IC50s = 56.4, 82.3, and 102 nM,...
| Keywords: | N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-benzamide,... |
| Application: | TAK1 (MAP3K7) inhibitor, MAP4K2 (GCK) inhibitor |
| MW: | 647 D |
From 84.00€
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GCK (MAP4K2), GST-tag
Item number: BPS-40107
Human GCK, also known as MAP4K2, GenBank Accession No. NM_004579, full length, with N-terminal GST tag, MW ~125 kDa, expressed in Sf9 insect cells via a baculovirus expression system.
| Keywords: | GCK, MAP4K2, MEKKK 2, GC kinase, EC=2.7.11.1, MEK kinase kinase 2, Germinal center kinase, Rab8-interacting protein,... |
| Application: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Expressed in: | insect cells |
| Origin: | human |
| MW: | 125 kD |
901.00€
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GNF-7
Item number: Cay19918-1
GNF-7 is a multi-kinase inhibitor (IC50s = 25, 8, 61, 122, 136, and 133 nM for ACK1, GCK, Bcr-AblT315I, Bcr-AblE255V, Bcr-AblG250E, and c-Abl, respectively). It also inhibits several additional kinases in a panel by greater than 50% when used at a concentration of 10 µM. GNF-7 inhibits the growth of Ba/F3 cells...
| Keywords: | N-[3-[1,4-dihydro-1-methyl-7-[(6-methyl-3-pyridinyl)amino]-2-oxopyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trif... |
| Application: | Ack1 / GCK inhibitor |
| CAS | 839706-07-9 |
| MW: | 547.5 D |
From 51.00€
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Anti-MAP4K2
Item number: ATA-HPA007330.100
Protein function: Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser...
| Keywords: | Anti-GCK, Anti-MAP4K2, Anti-MEKKK 2, Anti-GC kinase, EC=2.7.11.1, Anti-MEK kinase kinase 2, Anti-Germinal center kinase,... |
| Application: | ICC, IHC |
| Host: | Rabbit |
| Species reactivity: | human |
From 369.00€
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Anti-MAP4K2
Item number: CSB-PA058535.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: MAP4K2. Antigen Species: Human
| Keywords: | Anti-GCK, Anti-MAP4K2, Anti-MEKKK 2, Anti-GC kinase, EC=2.7.11.1, Anti-MEK kinase kinase 2, Anti-Germinal center kinase,... |
| Application: | ELISA, WB |
| Host: | Rabbit |
| Species reactivity: | human, mouse |
From 167.00€
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Anti-MAP4K2
Item number: CSB-PA294869.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: MAP4K2. Antigen Species: Human
| Keywords: | Anti-GCK, Anti-MAP4K2, Anti-MEKKK 2, Anti-GC kinase, EC=2.7.11.1, Anti-MEK kinase kinase 2, Anti-Germinal center kinase,... |
| Application: | ELISA, WB |
| Host: | Rabbit |
| Species reactivity: | human, mouse |
From 167.00€
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GNF-7
Item number: TGM-T3196-100mg
Description: GNF-7 is Bcr-Abl WT and Bcr-Abl T315I inhibitor with IC50 of 133 nM and 61 nM, respectively. Target: AChR, Bcr-Abl, ACK. Smiles: CN1C(=O)N(Cc2cnc(Nc3ccc(C)nc3)nc12)c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C. References: Choi HG, et al. J Med Chem. 2010, 53(15), 5439-5448.
| Keywords: | GNF7 |
| Application: | Ack1 / GCK inhibitor |
| CAS | 839706-07-9 |
| MW: | 547.53 D |
From 36.00€
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Germinal Center Kinase/MAP4K2 Protein, Human, Recombinant...
Item number: TGM-TMPY-04412-50ug
Description: Mitogen-activated protein kinase kinase kinase kinase 2, also known as B lymphocyte serine/threonine-protein kinase, Germinal center kinase, MAPK/ERK kinase kinase kinase 2, MEK kinase kinase 2, Rab8-interacting protein, and MAP4K2, is cytoplasm and peripheral membrane protein that belongs to the...
| Keywords: | GCK, mitogen-activated protein kinase kinase kinase kinase 2, RAB8IP, MAP4K2, BL44 |
| MW: | 119 kD |
545.00€
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TL4-12
Item number: Cay42907-1
TL4-12 is an inhibitor of MAP4K2 (IC50 = 37. nM). It is selective for MAP4K2 over 20 other kinases at 1 µM. TL4-12 (500 nM) inhibits IL-1alpha- or TGF-beta-induced increases in p38 phosphorylation in primary mouse embryonic fibroblasts. It induces apoptosis in MM.1S multiple myeloma cells when used at concentrations...
| Keywords: | 4-methyl-3-[[6-(methylamino)-4-pyrimidinyl]oxy]-N-[3-(4-methyl-1-piperazinyl)-5-(trifluoromethyl)phenyl]-benzamide |
| Application: | MAP4K2 inhibitor |
| CAS | 1620820-12-3 |
| MW: | 500.53 D |
From 47.00€
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NEW
Recombinant Human MAP4K2 Protein
Item number: ABS-PQ-4525-L.100
Tag: N-MBP & C-His. Modification: unmodified. Start Site: Arg221. End Site: Pro340. Coverage: 0.16. Isoelectric Point: 7. Core Sequence: RALMLMSKSS FQPPKLRDKT RWTQNFHHFL KLALTKNPKK RPTAEKLLQH PFTTQQLPRA LLTQLLDKAS DPHLGTPSPE DCELETYDMF PDTIHSRGQH GPAERTPSEI QFHQVKFGAP. Homologies: Highest protein sequence identity...
| Keywords: | MAP4K2, Germinal center kinase, Rab8-interacting protein, MAPK/ERK kinase kinase kinase 2, B lymphocyte... |
| Expressed in: | Human cells |
| Origin: | human |
| MW: | 58 kD |
From 295.00€
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NEW
Recombinant Human MAP4K2 Protein
Item number: ABS-PQ-4525.100
Tag: N-MBP & C-His. Modification: unmodified. Start Site: Arg221. End Site: Pro340. Coverage: 0.16. Isoelectric Point: 7. Core Sequence: RALMLMSKSS FQPPKLRDKT RWTQNFHHFL KLALTKNPKK RPTAEKLLQH PFTTQQLPRA LLTQLLDKAS DPHLGTPSPE DCELETYDMF PDTIHSRGQH GPAERTPSEI QFHQVKFGAP. Homologies: Highest protein sequence identity...
| Keywords: | MAP4K2, Germinal center kinase, Rab8-interacting protein, MAPK/ERK kinase kinase kinase 2, B lymphocyte... |
| Expressed in: | Human cells |
| Origin: | human |
| MW: | 58 kD |
From 270.00€
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TAK1/MAP4K2 inhibitor 1
Item number: TGM-T10444-5mg
Description: TAK1/MAP4K2 inhibitor 1 is a potent dual inhibitor of TGFbeta-activated kinase 1 (TAK1) and MAP4K2 [IC50s: 41.1 nM and 18.2 nM]. Target: Others. Smiles: CCN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(Oc4ncnc5[nH]c(C)cc45)c3)cc2C(F)(F)F)CC1. References: Tan L, et al. Discovery of type II inhibitors of TGFbeta-activated...
| Application: | TAK1/MAP4K2 inhibitor |
| CAS | 1315330-11-0 |
| MW: | 552.59 D |
From 115.00€
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