76 products were found matching "K04410"!

Protein function: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active...

Rabbit Polyclonal PAK2 Antibody against Human p21 (RAC1) activated kinase 2. Validated for Western Blot. Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Interspecies information: Highest antigen sequence indentity to the following orthologs: ENSMUSG00000022781: 87%,...

Rabbit Polyclonal PAK2 Antibody against Human p21 (RAC1) activated kinase 2. Validated for Western Blot. Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Interspecies information: Highest antigen sequence indentity to the following orthologs: ENSMUSG00000022781: 87%,...

Rabbit Polyclonal PAK2 Antibody against Human p21 (RAC1) activated kinase 2. Validated for Western Blot. Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Interspecies information: Highest antigen sequence indentity to the following orthologs: ENSMUSG00000022781: 98%,...

A PAK2 inhibitor (IC50 = 10 nM) and an immunosuppressant, inhibits concanavalin A-induced production of IL-2 in Jurkat T cells (IC50 = 400 nM), decreases disease severity, serum IgE levels, and skin thickness in the NC/Nga mouse model of atopic dermatitis when applied topically at 0.1%, reduces cutaneous nerve fiber...

FRAX597 is an inhibitor of p21-activated kinase (PAK) that is selective for group I PAKs (IC50s = 7.7, 12.8, and 19.3 nM for PAK 1, 2, and 3, respectively) over group II PAKs (IC50 > 10 µM for PAK4 and 50 = 70 nM), prevents proliferation of transformed Schwann cells by halting the cell cycle in the G1 phase, and...

Description: FRAX597 is an effective, ATP-competitive inhibitor of group I PAKs, and for PAK1(IC50=8 nM), PAK2(IC50=13 nM), and PAK3 (IC50=19 nM). Target: PAK. Smiles: CCn1c2nc(Nc3ccc(cc3)N3CCN(C)CC3)ncc2cc(-c2ccc(cc2Cl)-c2cncs2)c1=O. References: Licciulli S, et al. J Biol Chem. 2013, 288(4), 29105-29114.

Protein function: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active...

Protein function: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active...

Active human PAK2 (GenBank Accession No. NM_002577), amino acids 227- 524, MW=33.5 kDa, expressed in E. coli.

Anti-PAK2 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with PAK2 from other sources has not been determined. Protein function: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton...

In 1X PBS, pH 7.4, with 0.09% sodium azide. PAK2, a member of the STE20 subfamily of Ser/Thr protein kinases, acts on a variety of targets. It phosphorylates ribosomal protein S6, histone H4 and myelin basic protein. PAK2 interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Expression is...