37 products were found matching "K04407"!

A MAP4K4 inhibitor (IC50 = 3 nM), selective for MAP4K4 over a panel of 141 kinases at 1 µM but does inhibit MAP4K6 and TNIK (IC50s = 6.61 and 10.96 nM, respectively), prevents hydrogen peroxide-induced decreases in viability in vCor.4U cells (EC50 = 3.16 nM), inhibits menadione-induced decreases in the OCR and ECAR...

A fluorescent mitochondrial probe, has been used to image actively respiring mitochondria in vitro, ex/em = 474/605 nm, respectively. Formulation: A solid. InChI: InChI=1S/C16H19N2.HI/c1-17(2)15-10-7-14(8-11-15)9-12-16-6-4-5-13-18(16)3,/h4-13H,1-3H3,1H/q+1,/p-1. InChIKey: XPOIQAIBZGSIDD-UHFFFAOYSA-M. SMILES:...

Protein function: Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322. [The UniProt Consortium]

GNE-495 is an orally bioavailable, potent, and selective MAP4K4 inhibitor (IC50 = 3.7 nM). In cell sprouting assays, it increases the number of protrusions. In a mouse model of oxygen-induced retinopathy, GNE-495 normalizes the percentage of pathological vessels and hemorrhagic areas.Formal Name:...

PF-6260933 is an inhibitor of mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4, IC50 = 3.7 nM). It is selective for MAP4K4 over a panel of 41 kinases at 1 µM but also inhibits TRAF2- and NCK-interacting kinase (TNIK) and misshapen-like kinase 1 (MINK1, IC50s = 15 and 8 nM, respectively). PF-6260933...

Description: GNE-495 is a potent and specific inhibitor of MAP4K4 with an IC50 of 3.7 nM. Target: MAPK. Smiles: Nc1ncc(C(=O)NC2CN(C2)C(=O)C2CC2)c2ccc(nc12)-c1cccc(F)c1. References: Ndubaku CO et al. Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis. ACS...

Protein function: Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322. [The UniProt Consortium]

Protein function: Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322. [The UniProt Consortium]

In 1X PBS, pH 7.4, with 0.09% sodium azide. HGK/NIK, a member of the STE20 subfamily of Ser/Thr protein kinases, may play a role in the response to environmental stress and cytokines such as TNF-alpha. It appears to act upstream of the JUN N-terminal pathway. This protein is thought to interact with the SH3 domain...

Protein function: Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr- 322. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added...

Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...

Description: PF-06260933 is a highly selective small-molecule MAP4K4 inhibitor with IC50s of 3.7 and 160 nM for kinase and cell, respectively. Target: MAPK. Smiles: Nc1ccc(cn1)-c1cnc(N)c(c1)-c1ccc(Cl)cc1. References: Ammirati M, et al. Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based...