- Search results for K04295
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25 products were found matching "K04295"!
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Item number: ELK-ELK7432.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse S1PR5. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse S1PR5. Next,...
Keywords: | S1P5, Edg8, S1pr5, S1P receptor 5, S1P receptor Edg-8, Lysophospholipid receptor B4, Sphingosine 1-phosphate receptor 5,... |
Application: | ELISA |
Species reactivity: | mouse |
From 365.00€
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Item number: ELK-ES6624.100
The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal...
Keywords: | Anti-EDG8, Anti-S1P5, Anti-S1PR5, Anti-S1P receptor 5, Anti-S1P receptor Edg-8, Anti-Sphingosine 1-phosphate receptor 5,... |
Application: | IHC, IF, ELISA |
Host: | Rabbit |
Species reactivity: | human, rat, mouse, |
From 169.00€
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Item number: Cay19922-5
Ozanimod is a sphingosine-1-phosphate receptor 1 (S1P1) and S1P5 agonist. It induces GTPgammaS binding in cell membranes expressing human S1P1 or S1P5 (EC50s = 0.41 and 11 nM, respectively) but not cell membranes expressing S1P2 or S1P3 receptors (EC50s = >10,000 nM for both). Ozanimod (0.2 mg/kg) reduces the number...
Keywords: | 5-[3-[(1S)-2,3-dihydro-1-[(2-hydroxyethyl)amino]-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)-benzonitrile |
Application: | S1PR1 / S1PR5 modulator, Immunomodulator |
CAS | 1306760-87-1 |
MW: | 404.5 D |
From 60.00€
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Item number: Cay22057-1
Siponimod is an agonist of sphingosine-1-phosphate receptor 1 (S1P1) and S1P5. It is selective for S1P1 and S1P5 over S1P2, S1P3, and S1P4 (EC50s = 0.39, 0.98, >10,000, >1,000, and 750 nM, respectively, in GTP-gammaS binding assays). Siponimod (10 nM) reduces demyelination induced by lysophosphatidylcholine or...
Keywords: | BAF312,... |
Application: | S1P receptor agonist |
CAS | 1230487-00-9 |
MW: | 516.6 D |
From 43.00€
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Item number: Cay25326-5
A-971432 is a sphingosine-1-phosphate receptor 5 (S1P5) agonist that is selective for S1P5 over S1P1 and S1P3 (IC50s = 0.006, 0.362, and >10 µM, respectively). It inhibits forskolin-induced cAMP production in CHO cells expressing S1P5 (EC50 = 4.1 nM). A-971432 (1 µM) increases electrical resistance of hCMEC/D3 cells...
Keywords: | 1-[[4-[(3,4-dichlorophenyl)methoxy]phenyl]methyl]-3-azetidinecarboxylic acid |
Application: | S1PR5 agonist |
CAS | 1240308-45-5 |
MW: | 366.2 D |
From 43.00€
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Item number: Cay13490-1
Sphingosine 1-phosphate (S1P) receptor EDG-8 is a multi-pass membrane protein belonging to the G protein-coupled receptor 1 family and coupled to both the Gi/0a and G12 subclass of heteromeric G-proteins. EDG-8 acts as a receptor for the bioactive sphingolipid S1P as well as for lysophosphatidic acid (LPA) and gives...
Keywords: | EDG-8, S1PR5, Sphingosine-1-phosphate Receptor 5 |
Application: | WB, IHC |
Host: | Rabbit |
Species reactivity: | human |
465.00€
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Item number: G-HUFI00629.96
Application: | ELISA |
Species reactivity: | human |
641.00€
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Item number: G-MOFI01092.96
Application: | ELISA |
Species reactivity: | mouse |
694.00€
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Item number: NSJ-R35907-100UG
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Endothelial differentiation, sphingolipid G-protein-coupled receptor, 8, sphingosine-1-phosphate receptor 5 (S1PR5) Protein function: Receptor for the lysosphingolipid sphingosine 1- phosphate...
Keywords: | Anti-EDG8, Anti-S1P5, Anti-S1PR5, Anti-S1P receptor 5, Anti-S1P receptor Edg-8, Anti-Sphingosine 1-phosphate receptor 5,... |
Application: | WB, ELISA (peptide) |
Host: | Goat |
Species reactivity: | human |
755.00€
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Item number: NSJ-F43818-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid...
Keywords: | Anti-EDG8, Anti-S1P5, Anti-S1PR5, Anti-S1P receptor 5, Anti-S1P receptor Edg-8, Anti-Sphingosine 1-phosphate receptor 5,... |
Application: | WB, ELISA |
Host: | Rabbit |
Species reactivity: | human |
From 326.00€
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Item number: Cay24159-10
Ceralifimod is an agonist of the sphingosine-1-phosphate (S1P) receptors S1P1 and S1P5 (Kis = 0.626 and 0.574 nM, respectively). It is selective for S1P1 and S1P5 over S1P2-4 (Kis = >5,450, >5,630, and 28.8 nM, respectively). Ceralifimod induces calcium influx in CHO-K1 cells overexpressing S1P1 (EC50 = 1 nM) and...
Keywords: | ONO-4641, 1-[[3,4-dihydro-6-[(2-methoxy-4-propylphenyl)methoxy]-1-methyl-2-naphthalenyl]methyl]-3-azetidinecarboxylic acid |
Application: | S1P1 / S1P5 agonist |
CAS | 891859-12-4 |
MW: | 435.6 D |
From 43.00€
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Item number: Cay31437-10
GSK2018682 is an agonist of sphingosine-1-phosphate receptor 1 (S1P1) and S1P5. It is selective for S1P1 and S1P5 over S1P2, S1P3, and S1P4 receptors. GSK2018682 is efficacious in a mouse model of experimental autoimmune encephalomyelitis (EAE).Formal Name:...
Keywords: | 4-[5-[5-chloro-6-(1-methylethoxy)-3-pyridinyl]-1,2,4-oxadiazol-3-yl]-1H-indole-1-butanoic acid |
Application: | S1P1 / S1P5 receptor agonist |
CAS | 1034688-30-6 |
MW: | 440.9 D |
From 92.00€
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