45 products were found matching "K04289"!

BMS 986278 is an antagonist of lysophosphatidic acid receptor 1 (LPA1, Kb = 0. µM). It is selective for LPA1 over a panel of 44 receptors, ion channels, and enzymes when used at concentrations ranging from 30 to 150 µM, including the bile salt export pump (BSEP), multidrug resistance protein 3 (MDR3), multidrug...

Lysophosphatidic acid (LPA) is a bioactive lipid mediator that signals through five distinct G protein-coupled receptors (LPA1-5). Ki16425 is a LPA receptor antagonist with selectivity for LPA1 and LPA3. It exhibits Ki values of 0.34, 6.5, and 0.93 µM for the human LPA1, LPA2, and LPA3 receptors, respectively, as...

LPA1 (also known as EDG-2) is one of four known LPA receptors (LPA1-4). LPA1-3 are part a family of G protein-coupled receptors that share identity to the sphingosine-1-phosphate receptors (S1P1-5). LPA1 couples with three types of G proteins, Gi/o, Gq, and G12/13 to induce a range of cellular responses including...

1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC is a phospholipid containing stearic acid (Cay-10011298) and docosahexaenoic acid (DHA, Cay-90310) at the sn-1 and sn-2 positions, respectively. It has been used in the study of lipid membrane organization and dynamics. The levels of...

AM966 is an orally bioavailable, potent, and selective antagonist of the lysophosphatidic acid receptor 1 (LPA1) that has an IC50 value of 17 nM in a calcium assay using CHO cells transfected with the human LPA1 receptor. It is selective for LPA1 over the LPA2, LPA3, LPA4, and LPA5 receptors (IC50s = 1,700, 1,600,...

1-Oleoyl-2-hydroxy-sn-glycero-3-PE is a naturally-occurring lysophospholipid and an analog of plasmalogen lysophosphatidylethanolamine. It induces transient increases in intracellular calcium in PC12 rat neuronal cells in a concentration-dependent manner, an effect that can be blocked by the lysophosphatidic acid...

BMS 986020 is an antagonist of lysophosphatidic acid receptor 1 (LPA1, Kb = 0.0067 µM). It is selective for LPA1 over LPA3 in CHO cells expressing the human receptors (IC50s = 0.3 and >1 µM, respectively). BMS 986020 also inhibits organic anion transporting polypeptide 1B1 (OATP1B1), OATP1B3, the bile salt export...

AM095 is an orally bioavailable antagonist of lysophosphatidic acid receptor 1 (LPA1) with IC50 values of 25 and 23 nM in CHO cells expressing human or mouse receptors, respectively. It is selective for LPA1 over LPA2, LPA3, LPA4, and LPA5 (IC50s = >10,000 nM for human LPA2-5). It inhibits chemotaxis of CHO cells...

1-Stearoyl-2-hydroxy-sn-glycero-3-PE is a lysophospholipid. It induces transient increases in intracellular calcium in PC12 rat neuronal cells in a concentration-dependent manner, an effect that can be blocked by the lysophosphatidic acid receptor 1 (LPA1) receptor antagonist AM095 (Cay-22141).Formal Name:...

Oleoyl ethanolamide phosphate (OEA-P) is a lysophosphatidic acid (LPA) mimetic, LPA receptor agonist, and phosphate ester of oleoyl ethanolamide (OEA, Cay-90265). It selectively increases [35S]GTPgammaS binding to HEK293T cell membranes expressing LPA1 and LPA2 over LPA3 receptors. OEA-P induces calcium mobilization...

ONO-7300243 is an antagonist of lysophosphatidic acid receptor 1 (LPA1, IC50 = 0.16 µM). It is selective for LPA1 over the LPA2 and LPA3 receptors (IC50s = 8.6 and >10 µM, respectively). ONO-7300243 dose-dependently reduces intraurethral pressure induced by LPA in rats (ID50 = 11.6 mg/kg) without affecting mean...