29 products were found matching "K04284"!

PF-05190457 is an inverse agonist of the growth hormone secretagogue receptor (GHS-R), which is also known as the ghrelin receptor. It selectively binds to GHS-R (Ki = 4.37 nM) over M2 muscarinic acetylcholine receptors (mAChRs, Ki = 1,950 nM) and the serotonin (5-HT) receptor subtype 5-HT2B (IC50 = 3,700 nM)....

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human GHSR. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human GHSR. Next,...

Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP). Protein function: Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP)...

Alexamorelin is a synthetic heptapeptide agonist of the growth hormone secretagogue receptor (GHS-R).Formal Name: L-alanyl-L-histidyl-2-methyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide, trifluoroacetate salt. Synonyms: Ala-His-D-2-Methyl-Trp-Ala-Trp-D-Phe-Lys-NH2. Molecular Formula: C50H63N13O7...

Hexarelin is a synthetic hexapeptide agonist of the growth hormone secretagogue receptor (GHS-R). It selectively binds to GHS-R over CD36 (IC50s = 15.9 and 2,080 nM, respectively). Hexarelin (300 µg/kg, s.c.) increases plasma growth hormone levels in neonatal rats. It also improves left ventricular function and...

Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor that stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis. JMV3002 is a potent ghrelin receptor antagonist with an IC50 value of 1.1 nM in vitro. At 80 µg/kg, JMV3002 inhibits...

GHRP-6 is a synthetic growth hormone (GH) secretagogue and an agonist of the GH secretagogue receptor (GHS-R), which is also known as the ghrelin receptor. It inhibits binding of the GHS-R agonist MK-0677 (ibutamoren, Cay-18003) to COS-7 cell membranes expressing human GHS-R type Ia (Ki = 1.9 nM) and binding of...

GHRP-2 is an orally bioavailable synthetic growth hormone (GH) secretagogue and an agonist of the GH secretagogue receptor (GHS-R), which is also known as the ghrelin receptor. It induces GH release from primary rat pituitary cells (EC50 = 1.8 nM) and binds to human hypothalamic membranes (IC50 = 16 nM). GHRP-2...

Protein function: Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine). [The UniProt...

Anamorelin is a small molecule agonist of the growth hormone (GH) secretagogue receptor 1a (GHS-R1a) and a mimetic of ghrelin (Cay-15072, Cay-24458, Ki = 0.7 nM). It induces calcium mobilization in CHO cells expressing rat GHS-R1a in a concentration-dependent manner and GH release from rat pituitary cells (EC50 =...

Ghrelin is an endogenous ligand for the growth hormone (GH) secretagogue receptor (GHSR). Ibutamoren is an orally-active, non-peptidic agonist of GHSR (Kd = 0.4 nM) and, as a result, is a GH secretagogue. It elevates GH in dogs after oral doses as low as 0.125 mg/kg, without significantly changing plasma levels of...