29 products were found matching "K04234"!

I-191 is an antagonist of proteinase-activated receptor 2 (PAR2, IC50 = 72.4 nM in HT-29 cells expressing the human receptor). It inhibits trypsin-induced calcium release in HT-29 cells (IC50 = 200 nM for the human receptor). I-191 (0.1, 1, and 10 µM) reduces the migration of HT-29 cells in a scratch assay. It...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat PAR2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat PAR2. Next,...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse PAR2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse PAR2. Next,...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human PAR2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human PAR2. Next,...

Proteinase-activated receptor 2 (PAR2) is a G protein-coupled receptor that is cleaved by serine proteases, resulting in self-activation of the receptor by a tethered ligand. The ligand corresponds to residues 39-44 (SLIGRL in mouse PAR-2). SLIGRL-NH2 is a recombinant peptide that activates PAR2 (EC50 = ~5 µM),...

FSLLRY-amide is a peptide antagonist of protease-activated receptor (PAR) 2 which blocks activation by trypsin (IC50 = ~50 µM) but not by the synthetic agonist SLIGRL-NH2 (Cay-16723). It does not affect thrombin-induced activation of PAR1 or trypsin-mediated proteolysis of casein. It can be used to study PAR2 action...

AC-55541 is a proteinase-activated receptor 2 (PAR2) agonist that displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation. It stimulates cell proliferation, phosphatidylinositol hydrolysis, and calcium mobilization in in vitro functional assays (pEC50s = 6.7,...

2-furoyl-LIGRLO amide is a potent and selective agonist of the proteinase-activated receptor, PAR2 (pD2 = 7.0). It does not activate PAR1 or PAR4. Through its effects on PAR2, 2-furoyl-LIGRLO amide produces a concentration-dependent relaxation of arteries previously contracted with alpha1 adrenergic receptor...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Protease activated receptor 2 (PAR2), also known ascoagulation factor II (thrombin) receptor-like 1 (F2RL1) or G-protein coupled receptor 11 (GPR11), is a protein that in humans is encoded by the F2RL1 gene. F2RL1 is a member of the large family of...

Protein function: Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I- kappaB kinase/NF-kappaB and Rho. Can also be...

PAR3 (1-6) amide is a synthetic hexapeptide that corresponds to amino acid residues 1-6 of the amino terminal tethered ligand sequence of mouse proteinase-activated receptor 3 (PAR3) and residues 38-43 of the full-length sequence. PAR3 (1-6) amide activates PAR1 and PAR2, but not PAR3 or PAR4. It does not induce...