34 products were found matching "K04224"!

Recombinant CHO-K1 cells stably overexpress human tachykinin receptor 3 (NK3) on the surface and contain high levels of G protein Galphaq to couple with the receptor in downstream signaling pathways.

An NK3 receptor antagonist (Ki = 0.013 µM), selective for NK3 over NK1 and NK2 receptors (Kis = >100 and 1.221 µM, respectively), inhibits senktide-induced contractions in isolated rabbit iris sphincter muscle preparations (Kb = 43 nM), inhibits substance P-induced contraction of longitudinal and circular smooth...

An NK3 receptor peptide agonist, binds NK3 receptors in isolated rat cerebral cortex (Ki = 2.5 nM), induces contractions in isolated and perfused carp intestinal bulb smooth muscle strips (EC50 = 39 nM), induces reciprocal hindlimb neck-scratching behavior in mice (ED50 = 0.08 nmol/animal, i.c.v.). Formulation: A...

GR73632 is a peptide neurokinin-1 (NK1) receptor agonist. It potentiates electrically induced contractions in isolated guinea pig vas deferens (EC50 = 2 nM). Intradermal administration of GR73632 (30 nmol/animal) increases scratching behavior in gerbils. It induces foot tapping behavior in gerbils when...

Senktide is a potent, selective agonist of the neuromedin K3 (NK3) receptor (EC50 = 0.5-3 nM). It less potently agonizes the NK1 receptor (EC50 = 35 µM) and is without effect on the NK2 receptor. Senktide is used to study the action of the NK3 receptor in cells and in animals.Formal Name:...

Eledoisin is an undecapeptide tachykinin neuropeptide and neurokinin (NK) receptor agonist originally isolated from E. moschata. It binds to NK1 (pD2 = 9.5 and 9.21 in isolated dog carotid artery and guinea pig ileum, respectively), NK2 (pD2 = 8.22 and 7.7 in isolated rabbit pulmonary artery and rat duodenum,...

Anti-NK3R Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with NK3R from other sources has not been determined. Protein function: This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that...

MLE-4901 is an antagonist of the neurokinin-3 (NK3) receptor. It inhibits human liver microsomal CYP3A4/5 with apparent IC50 values of 7.1 and 19.8 µM in midazolam 1'-hydroxylation and testosterone 6beta-hydroxylation assays, respectively.Formal Name:...

Protein function: This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P. [The...

SB 222200 is a neurokinin-3 (NK3) receptor antagonist (IC50 = 18.4 nM). It is selective for NK3 over NK1 and NK2 receptors (IC50s = 250 and >100,000 nM, respectively). SB 222200 decreases calcium mobilization induced by neurokinin B (Cay-24542) with an IC50 value of 265 nM in HEK293 cells expressing the recombinant...

SCH 60057 is a fungal metabolite that has been found in Acremonium and a neurokinin receptor (NK) antagonist (IC50s = 6 and 12 µM for NK1 and NK2, respectively).Formal Name: 3,7,11,15,19,23,27,31,35-nonamethyl-2E,6E,10E,34-hexatriacontatetraene-1,15,19,23,27,31-hexol. CAS Number: 203061-35-2. Molecular Formula:...