60 products were found matching "K04218"!

Recombinant CHO-K1 cells stably overexpress human somatostatin receptor 2 (SST2) on the surface and contain high levels of G protein Galphai to couple with the receptor in downstream signaling pathways.

Octreotide is an octapeptide analog of somatostatin that binds to somatostatin receptors (SSTRs) with a higher affinity for the somatostatin subgroup 2 receptors, SST2, SST3, and SST5 (Kis = 875, 0.57, 26.8, >1,000, and 6.8 nM for SST1-5 receptors, respectively). Within subgroup 2 SSTRs, it selectively binds to SST2...

Pasireotide is a somatostatin receptor (SSTR) agonist that binds selectively to SST1, SST2, SST3, and SST5 over SST4 (IC50s = 9.3, 1, 1.5, 0.16, and >100 nM, respectively, for human recombinant receptors). It dose-dependently inhibits growth hormone release stimulated by growth hormone-releasing hormone (GHRH) in...

Lanreotide is a peptide analog of somatostatin that binds to somatostatin receptors (SSTRs) with a higher affinity for the somatostatin subgroup 2 receptors SST2, SST3, and SST5 (IC50s = 0.5-1.8, 43-107, and 5.6-32 nM, respectively) than for the subgroup 1 receptors, SST1 and SST4 (IC50s = 500-2,330 and 66-2,100 nM,...

Cortistatin-14 is an endogenous neuropeptide agonist of somatostatin receptors (IC50s = 0.5-18.2 nM for human SST1-SST5 receptors expressed in CCL39 cells). It is expressed in GABAergic interneurons in the cortex and hippocampus. Cortistatin-14 competitively inhibits hexarelin binding to human growth hormone...

Protein function: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by...

Protein function: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by...

CYN 154806 is a cyclic peptide somatostatin receptor 2 (SST2) antagonist (IC50 = 2.62 nM). It is selective for SST2 over SST1, SST3, SST4, and SST5 (IC50s = 3,890, 851, 1,737, and 331 nM, respectively). CYN 154806 inhibits SST-induced increases in extracellular acidification (EAR) in CHO-K1 cells expressing...

Organism: Homo sapiens (Human). Source: in vitro E.coli expression system. Expression Region: 1-369aa. Protein Length: Full Length. Tag Info: N-terminal 10xHis-tagged. Target Protein Sequence: MDMADEPLNG SHTWLSIPFD LNGSVVSTNT SNQTEPYYDL TSNAVLTFIY FVVCIIGLCG NTLVIYVILR YAKMKTITNI YILNLAIADE LFMLGLPFLA MQVALVHWPF...

Organism: Homo sapiens (Human). Source: Mammalian cell. Expression Region: 1-369aa. Protein Length: Full Length. Tag Info: C-terminal 6xHis-tagged (This tag can be tested only under denaturing conditions). Target Protein Sequence: MDMADEPLNG SHTWLSIPFD LNGSVVSTNT SNQTEPYYDL TSNAVLTFIY FVVCIIGLCG NTLVIYVILR...

Protein function: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by...