32 products were found matching "K04216"!

Following the cloning of the classical opioid receptors (mu, delta and kappa), the opiate receptor like-1 (ORL1) was identified as a G-protein coupled receptor (GPCR) with 65% structure homology to the other members of the opioid family. OPRL1 is a receptor for the 17 aa neuropeptide nociceptin/orphanin FQ and may...

Rabbit Polyclonal OPRL1 Antibody against Human opioid related nociceptin receptor 1. Validated for Western Blot. Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Interspecies information: Highest antigen sequence indentity to the following orthologs: ENSMUSG00000027584: 77%,...

Nociceptin (1-11) is a peptide fragment of nociceptin (Cay-15070) and a ligand for the nociceptin opioid peptide (NOP) receptor. It binds NOP receptor 1 (Ki = 1. µM). Nociceptin (1-11) inhibits forskolin-induced cAMP accumulation in CHO cells expressing NOP receptor 1 (EC50 = 3. µM). It (5 or 10 µg) increases the...

SCH 221510 is an agonist of nociceptin opioid peptide (NOP) receptor. It induces [35S]GTPgammaS binding to CHO membranes expressing recombinant human NOP receptors (EC50 = 12 nM). SCH 221510 (10 mg/kg) increases time spent in the open arms and number of open arm entries in an elevated plus maze in rats. It increases...

Nociceptin is a 17 amino acid neuropeptide involved in a variety of biological systems including pain, memory, stress responses, anxiety, locomotion, and feeding behavior. It is an endogenous ligand of the NOP1 (ORL1) receptor (Ki = 88 µM in CHO cells) and, though an opioid-related peptide, does not interact...

JTC 801 is an antagonist of the nociceptin receptor (ORL1, Ki = 44.5 nM, IC50 = 94 nM) that is >100-, >100-, and >3-fold more selective for ORL1 over the related delta-, kappa-, and µ-opioid receptors, respectively. It demonstrates anti-nociceptive effects in acute pain models in mice upon oral administration at 1...

Cebranopadol is an agonist of nociceptin-, µ-, ?-, and delta-opioid receptors (Kis = 0.9, 0.7, 2.6, and 18 nM, respectively). It is greater than 100-fold selective for these receptors over a panel of more than 100 ion channels, neurotransmitter transporters, receptors, and enzymes, but does bind to the serotonin...

The protein encoded by this gene is a G protein-coupled receptor whose expression can be induced by phytohemagglutinin. The encoded integral membrane protein is a receptor for the 17 aa neuropeptide nociceptin/orphanin FQ. This gene may be involved in the regulation of numerous brain activities, particularly...

AT-121 is a dual µ-opioid and nociceptin receptor partial agonist (Kis = 16.49 and 3.67 nM, respectively). It stimulates [35S]GTPgammaS binding to cell membranes expressing µ-opioid or nociceptin receptors (EC50s = 19.6 and 34.7 nM, respectively). AT-121 (0.003-0.03 mg/kg) decreases capsaicin-induced thermal...

Protein function: G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G...

BAN ORL 24 is an antagonist of the nociceptin (NOP) receptor (Ki = 0.24 nM in a radioligand binding assay using CHO cell membranes expressing the human receptor). It is selective for NOP receptors over µ-, delta-, and kappa-opioid receptors (Kis = 0.19, 0.34, and >1 µM, respectively). BAN ORL 24 reduces NOP-induced...