53 products were found matching "K04202"!

PT-141 is a cyclic peptide agonist of melanocortin receptor 4 (MC4R) and an analog of alpha-melanocyte stimulating hormone (alpha-MSH, Cay-29923). It binds to MC3R and MC4R and increases intracellular cAMP levels in HEK293 cells expressing MC4R. It increases dopamine release in the medial preoptic area (mPOA) of the...

THIQ is a melanocortin 4 receptor (MC4R) agonist that is selective over MC1R, MC3R, and MC5R human receptors expressed in CHO cells (IC50s = 1.2, 2,067, 761, and 326 nM, respectively). It selectively increases cAMP accumulation in CHO cells expressing human MC4R over MC1R, MC3R, and MC5R (EC50s = 2.1, 2,850, 2,487,...

Solulibility: Acetonitrile: Slightly soluble: 0.1-1 mg/ml: DMSO: Sparingly soluble: 1-10 mg/ml.

JKC363 is a cyclic peptide antagonist of melanocortin receptor 4 (MC4R) (IC50 = 0. nM). It is selective for MC4R over MC3R (IC50 = 44. nM). JKC363 (100 nM) decreases basal thyrotropin-releasing hormone (TRH) secretion and alpha-melanocyte-stimulating hormone- (alpha-MSH-) or gamma2-MSH-induced TRH secretion in rat...

Setmelanotide is a cyclic peptide agonist of melanocortin receptor 4 (MC4R). It increases cAMP production in CHO-K1 cells expressing MC4R, MC1R, MC3R, and MC5R (EC50s = 0.27, 5.8, 5.3, and 1,600 nM, respectively, for the human receptors) but not in cells expressing MC2R (EC50 = >10 µM). Setmelanotide (6.4...

Melanocortins are known to exert a broad array of physiological actions including 'melanogenesis, steroidogenesis, sexual function and inflammation, as well as appetite regulation and energy homeostasis'. These actions are mediated (differentially or concurrently) in part by a family of G protein-coupled receptors,...

SHU9119 is an agonist of melanocortin receptor 1 (MC1R) and antagonist of MC4R (IC50s = 1.2 and 2.9 nM, respectively, for displacement of melanocortin). It induces cAMP formation in HEK293 cells expressing human MC1R (EC50 = 1.11 nM), but inhibits cAMP formation in cells expressing human MC4R. In rats, SHU9119 (24...

Protein function: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). [The UniProt Consortium]

Anti-MC4R Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with MC4R from other sources has not been determined. Protein function: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a...

The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity Protein...

ML-00253764 is a melanocortin receptor 4 (MC4R) antagonist (Ki = 0.16 µM). It is selective for MC4R over MC3R and MC5R (IC50s = 0.32, 0.81, and 2.12 µM, respectively). ML-00253764 (100 µM) decreases cAMP production induced by [NLE4,D-Phe7]-alpha-melanocyte stimulating hormone ([NDP]-alpha-MSH, Cay-24475) by 20% in...