71 products were found matching "K04197"!
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Anti-Recombinant Endothelin A Receptor, clone C111853
Item number: E-AN302233L.100
Protein function: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 [The UniProt Consortium]
| Keywords: | Anti-EDNRA, Anti-Endothelin-1 receptor, Anti-Endothelin receptor type A, Recombinant Endothelin A Receptor Monoclonal... |
| Application: | WB, IHC, IF, ELISA |
| Host: | Rabbit |
| Species reactivity: | human,mouse,rat |
From 171.00€
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Human ETRA (Endothelin Receptor A) Microsample ELISA Kit
Item number: ELK-ELK3033MS.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human ETRA. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human ETRA. Next,...
| Keywords: | EDNRA, Endothelin-1 receptor, Endothelin receptor type A |
| Application: | ELISA |
| Species reactivity: | human |
From 374.00€
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Mouse ET-1 (Endothelin1) Microsample ELISA Kit
Item number: ELK-ELK2397MS.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse ET-1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse ET-1. Next,...
| Keywords: | Ednra, Endothelin-1 receptor, Endothelin receptor type A |
| Application: | ELISA |
| Species reactivity: | mouse |
From 374.00€
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EDNRA Protein, Human, Recombinant (His)
Item number: TGM-TMPH-01294-10ug
Description: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.
| Keywords: | Endothelin receptor type A (ET-A,ETA-R,hET-AR) , EDNRA , Endothelin-1 receptor , ETA , ETRA |
| MW: | 8.8 kD |
From 81.00€
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Ambrisentan
Item number: TGM-T1655-5mg
Description: Ambrisentan (BSF 208075) is an endothelin receptor antagonist used in the therapy of pulmonary arterial hypertension (PAH). Ambrisentan has been associated with a low rate of serum enzyme elevations during therapy but has yet to be implicated in cases of clinically apparent acute liver injury. Target:...
| Keywords: | BSF 208075, BSF-208075, LU 208075 |
| Application: | Targets endothelin receptor type A (EDNRA) |
| CAS | 177036-94-1 |
| MW: | 378.42 D |
From 30.00€
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BQ-123 sodium salt
Item number: AG-CP3-0001-M001
Potent and selective endothelin receptor A (ETA) antagonist, suppresses the ET-1-induced decrease of LPL activity, shows protective effects in ischemic acute renal failure, neuroprotective, anti-hypertensive, inhibits ET-1 receptor binding and blocks Ca2 mobilization, cellular contraction and MAP kinase activation,...
| Keywords: | Endothelin Receptor A Antagonist BQ-123, cyclo(-D-Trp-D-Asp-Pro-D-Val-Leu) Na |
| Application: | Endothelin receptor A antagonist |
| CAS | 136553-81-6 |
| MW: | 609,7 D |
From 116.00€
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Macitentan
Item number: Cay23304-100
Macitentan is a dual antagonist of the endothelin (ET) receptors type A and B (IC50s = 0.5 and 391 nM in a radioligand binding assay using recombinant ETA and ETB, respectively). Macitentan inhibits intracellular Ca2+ increases induced by the endothelin isoform ET-1 in human pulmonary arterial smooth muscle cells...
| Keywords: | ACT-064992, N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propyl-sulfamide |
| Application: | Dual EDNRA / EDNRB antagonist |
| CAS | 441798-33-0 |
| MW: | 588.3 D |
From 60.00€
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Ambrisentan
Item number: Cay23669-5
Ambrisentan is a nonpeptide endothelin A (ETA) receptor antagonist (IC50s = 0.251, 0.316, 0.398, 251, and 630 nM for rat preparations of heart, bladder, kidney, lung, and cerebral cortex, respectively). It inhibits contraction of isolated rabbit aortic rings induced by endothelin-1 (ET-1, Cay-24127) by 43.23% when...
| Keywords: | alphaS-[(4,6-dimethyl-2-pyrimidinyl)oxy]-beta-methoxy-beta-phenyl-benzenepropanoic acid |
| Application: | Endothelin A (ETA) receptor antagonist |
| CAS | 177036-94-1 |
| MW: | 378.4 D |
From 51.00€
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Sitaxentan (sodium salt)
Item number: Cay29244-5
Sitaxentan is a potent nonpeptide endothelin A (ETA) receptor antagonist (IC50 = 1.4 nM). It is selective for ETA over ETB receptors (IC50 = 9,800 nM). Sitaxentan inhibits phosphoinositol hydrolysis induced by endothelin-1 (Cay-24127) in COS-7 cells (pA2 = 8). In vivo, sitaxentan reduces blood pressure in a rat...
| Keywords: | TBC 11251, Thelin, N-(4-chloro-3-methyl-5-isoxazolyl)-2-[2-(6-methyl-1,3-benzodioxol-5-yl)acetyl]-3-thiophenesulfonamide,... |
| Application: | Potent endothelin A receptor antagonist |
| CAS | 210421-74-2 |
| MW: | 476.9 D |
From 70.00€
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Bosentan-d4
Item number: Cay22097-25
Bosentan-d4 is an internal standard for the quantification of bosentan (Cay-11731) by GC- or LC-MS. Bosentan is an antagonist of the endothelin receptors type A (Ki = 6.5 nM) and type B (Ki = 340 nM).Formal Name:...
| Keywords: | 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy-1,1,2,2-d4)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-benzenesulfonamide |
| Application: | GC-MS, LC-MS, internal standard |
| CAS | 1065472-77-6 |
| MW: | 555.6 D |
From 421.00€
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Human ETRA / Endothelin A Receptor ELISA Kit
Item number: G-HUFI02432.96
| Application: | ELISA |
| Species reactivity: | human |
698.00€
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Kendomycin
Item number: BVT-0001-C100
Antibiotic, Potent endothelin receptor antagonist, Anti-osteoporotic, Antibacterial, Cytotoxic, Mediates its cytotoxic effects, at least in part, through proteasome inhibition. Isolated from Streptomyces violaceoruber.
| Keywords: | (-)-TAN 2162 |
| Application: | Endothelin receptor antagonist |
| CAS | 183202-73-5 |
| MW: | 486,6 D |
From 95.00€
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