201 products were found matching "K04189"!

The alpha-chemokine receptor, CXCR4, on CD4+ T-cells is used by CXCR4-selective HIV forms as a gateway for T-cell infection. In mammalian cell signaling, CXCR4 activation promotes the homing of hematopoietic stem cells, chemotaxis and quiescence of lymphocytes, and growth and metastasis of certain cancer cell types....

TC 14012 is a peptidomimetic antagonist of chemokine (C-X-C motif) receptor 4 (CXCR4, IC50 = 2.9 nM) and CXCR7 agonist. It induces beta-arrestin recruitment in HEK293T cells expressing CXCR7 (EC50 = 350 nM). TC 14012 reduces the cytopathic effect of HIV in infected MT-4 cells (EC50 = 0.4 nM) and inhibits HIV entry...

C-X-C chemokine receptor 4 (CXCR4) is a receptor for the stromal cell-derived factor-1 (SDF-1) which is designated as chemokine ligand 12 (CXCL12). It is involved in cell progression, hematopoiesis, cancer, HIV entry, and rheumatoid arthritis. FC 131 is an inhibitor of CXCR4 activation by SDF-1 (IC50 = 4.5 nM) and...

Mavorixafor is a chemokine (C-X-C motif) receptor 4 (CXCR4) antagonist (IC50 = 13 nM in a radioligand binding assay). It is selective for CXCR4 over chemokine (C-C motif) receptor 1 (CCR1), CCR2b, CCR4, CCR5, CXCR1, and CXCR2 (IC50s = >10 µM for all). Mavorixafor reduces chemotaxis of CCRF-CEM T cells induced by...

C-X-C chemokine receptor type 4 is a receptor for the stromal cell-derived factor-1 which is designated as chemokine ligand 12 (CXCL12). It is involved in cell progression, hematopoiesis, cancer, HIV entry, and rheumatoid arthritis. AMD 3465 blocks the cell surface binding of CXCL12 with an IC50 value of 18 nM. It...

This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been...

The CXC chemokine receptor-4 (CXCR4) is a G protein-coupled receptor that is specific for stromal cell-derived factor-1 (SDF-1/ CXCL12). Activation of CXCR4 promotes homing of hematopoietic stem cells, chemotaxis and quiescence of lymphocytes, and growth and metastasis of certain cancer cell types. Moreover, CXCR4...

Protein function: Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a...

Anti-CXCR4-Lo Antibody is purified via Protein A column purification. This antibody is specific for the longer isoform of CXCR4. Protein function: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Chemokine CXC Motif Receptor 4 is the receptor for the CXC chemokine SDF1 that has essential functions on embryo organogenesis, immunological functions and T lymphocyte trafficking. It is the only SDF1 receptor identified so far. This suggests that expression is...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Chemokine,CXC Motif, Receptor 4, also known as FUSIN or NPY3R, is a protein that in humans is encoded by the CXCR4 gene. By PCR analysis of human/hamster hybrid cell DNA, Herzog et al.(1993) showed that the NPY3R gene is located on human chromosome 2. Feng et...