38 products were found matching "K04147"!

A dopamine D4 receptor antagonist (Ki = 2.2 nM), selective for dopamine D4 receptors over dopamine D2L, D2S, and D3 receptors (Kis = 3,400, 6,300, and 5,300 nM, respectively), reduces amphetamine-induced hyperactivity in rats 7.5, 15, and 30 mg/kg. Formulation: A solid. InChI:...

Olanzapine is an atypical antipsychotic. Olanzapine had high affinity for dopamine D1, D2, D4, serotonin (5HT)2A, 5HT2C, 5HT3, alpha 1-adrenergic, histamine H1, and five muscarinic receptor subtypes.

(S)-Pramipexole is a dopamine D2S, D2L, D3, and D4 receptor agonist (EC50s = 426.58, 338.84, 2.24, and 128.82 nM, respectively, in a [35S]GTPgammaS binding assay). It is also a partial agonist of alpha2A-adrenergic receptors (alpha2A-ARs, EC50 = 3,548.13 nM). (S)-Pramipexole is selective for dopamine D2-4 receptors...

N,N-Dipropyldopamine is a dopamine receptor agonist. It decreases dihydrophenylalanine (DOPA) levels in the limbic forebrain and striatum of reserpinized rats (ED50s = 25 and 20 µmol/kg, respectively), as well as reduces homovanillic acid (HVA, Cay-27307) levels in rat striatum when administered at a dose of 80...

Protein function: Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating...

The Guinea Pig IL-8 Do-It-Yourself ELISA contains capture antibody, standard, and detection antibody for development of a Guinea Pig IL-8 ELISA. The antibodies have been determined to function in an ELISA with the standard provided. Optimal buffers, concentrations, incubation times, incubation temperatures, and...

RBI 257 is a potent dopamine D4 receptor antagonist (Ki = 0.3 nM) that is selective over D2L, D3, D2-like, and D1 receptors by 1,721-, 439-, 1,336-, and 8,576-fold, respectively.Formal Name: N-[1-[(4-iodophenyl)methyl]-4-piperidinyl]-N-methyl-3-(1-methylethoxy)-2-pyridinamine (2Z)-2-butenedioate. CAS Number:...

This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic...

Pramipexole (Cay-11981) is an agonist of dopamine receptors that has applications in Parkinson's disease and other disorders. Pramipexole is usually available as a mixture of enantiomers, with the majority of the dopamine receptor-dependent activity resulting from the (S) form. (R)-Pramipexole is an enantiomer of...

Sonepiprazole is a selective antagonist of the dopamine 4 (D4) receptor (Kis = 10 nM). It is highly selective over D1, D2, and D3 receptors, serotonin 1A and 2 receptors, as well as alpha1- and alpha2-adrenergic receptors (Kis > 2,000 nM). Its safety profile in rat studies is improved in comparison to classical...

Fluoroclebopride is a benzamide analog that is used in positron emission tomography (PET) applications. It binds reversibly to dopamine receptors (Kis = 0.95, 5.7, 5.46, and 144 nM for D2-like, D2(long), D3, and D4 receptors, respectively, in radioligand binding assays). It is selective for these receptors over D1,...

ABT-724 is a dopamine D4 receptor agonist with an EC50 value of 12.4 nM in a FLIPR calcium flux assay using HEK293 cells expressing the human D4.4 receptor and Galphaqo5. It is selective for dopamine D4 over D2 receptors at 10 µM. ABT-724 (0.03 µmol/kg) induces penile erections in 77% of male rats. It decreases...