58 products were found matching "K04136"!

Recombinant CHO-K1 cells stably overexpress human adrenoceptor alpha 1B (ADRA1B) on the surface and contain high levels of G protein Galphaq to couple with the receptor in downstream signaling pathways.

2-PMDQ is an antagonist of alpha1-adrenergic receptors (alpha1-ARs, Ki = 1. nM). It is selective for alpha1-ARs over alpha2-ARs (Ki = 962 nM). 2-PMDQ has antihypertensive activity in anesthetized rats (ED50 = 0. mg/kg).. Solulibility: DMSO: Slightly soluble: 0.1-1 mg/ml: .

(-)-Norepinephrine is the endogenous isomer of (±)-norepinephrine (Cay-35580) that acts as a neurotransmitter and hormone and is biosynthesized from dopamine by dopamine beta-hydroxylase. It is an agonist of adrenergic receptors (Ki values are 330, 56, and 740 nM for alpha1, alpha2, and beta1 adrenoceptors,...

Urapidil is an antagonist of alpha1-adrenergic receptors (alpha1-ARs) and a partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A. It selectively binds to alpha1- over alpha2-ARs (IC50s = 0.74 and 42 µM, respectively) and to 5-HT1A over 5-HT1B and 5-HT2 receptors (IC50s = 0.4, 20.4, and >10 µM,...

Doxazosin is a non-selective antagonist of alpha1-adrenergic receptors (alpha1-ARs, Kis = 3.16, 1, and 3.98 nM for alpha1A­-, alpha1B-, and alpha1D-ARs, respectively). It inhibits norepinephrine-induced contractions in isolated rat aorta rings and human prostate strips with pA2 values of 8.8 and 8.2, respectively....

Rec 15/2615 is an antagonist of alpha1B-adrenergic receptors (alpha1B-ARs, Ki = 0.45 nM for the recombinant human receptor). It selectively inhibits alpha1B-ARs over alpha1A-, alpha1D-, and alpha1L-ARs (Kis = 7.59, 10.23, and 49 nM, respectively). Rec 15/2615 inhibits norepinephrine-induced contractions of isolated...

Midodrine is a prodrug form of the alpha1-adrenergic receptor (alpha1-AR) agonist desglymidodrine (Cay-35608). It is converted to desglymidodrine by enzymatic hydrolysis. Midodrine (5 mg/kg) increases mean arterial pressure (MAP) and decreases heart rate in normotensive rats. Formulations containing midodrine have...

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Alpha-1B adrenoceptor Protein function: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system....

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Alpha-1B-adrenergic receptor Protein function: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger...

Prazosin is an antagonist of alpha1-adrenergic receptors (alpha1-ARs). It selectively binds to alpha1-ARs with Ki values of 0.2, 0.25, and 0.32 nM for the human recombinant alpha1A-, alpha1B-, and alpha1D-ARs, respectively, over alpha2-ARs (Kis = 340 and 3.7 nM in alpha2A-AR-expressing HT-29 cells and...

Tamsulosin is a potent antagonist of alpha1-adrenergic receptors (alpha1-ARs, Ki = 0.229 nM in a radioligand binding assay). It is 3,800-fold selective for alpha1-ARs over alpha2-ARs (Ki = 871 nM). Tamsulosin antagonizes norepinephrine-induced contraction of isolated rabbit aorta (pA2 = 10.11) but has no effect on...

A potent and highly selective antagonist of human alpha 1a-adrenoceptor.