84 products were found matching "K02516"!

Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and...

PF-06939999 is an inhibitor of protein arginine methyltransferase 5 (PRMT5, Ki = <5 pM). It is selective for PRMT5 over a panel of 22 additional protein methyltransferases and a panel of 40 kinases at 10 µM. PF-06939999 decreases global symmetric dimethyl arginine levels (IC50 = 1. nM) but does not affect histone...

PF-06855800 is an inhibitor of protein arginine methyltransferase 5 (PRMT5, Ki = 11 pM). It is selective for PRMT5 over a panel of 22 additional protein methyltransferases and a panel of 40 kinases at 10 µM. PF-06855800 inhibits the proliferation of A2780 ovarian cancer cells (IC50 = 3.3 nM). It also inhibits the...

LLY-284 is a diastereomer of the protein arginine methyltransferase 5 (PRMT5) inhibitor LLY-283 (Cay-21596). It weakly inhibits PRMT5 (IC50 = 1,074 nM). LLY-284 (100 µM) inhibits the asexual growth of P. falciparum in vitro.. Solulibility: DMSO: Soluble: = 10 mg/ml: Ethanol: Soluble: = 10 mg/ml.

Protein function: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, PubMed:12411503, PubMed:15737618, PubMed:17709427,...

Active human PRMT5 (GenBank Accession No. NM_006109), amino-acids 2-end, with N-terminal DDDDK tag (FLAG), MW=73 kDa, expressed in a FreeStyle 293-F cells.

Active human PRMT5 (GenBank Accession No. NM_006109), amino-acids 2-end, with N-terminal DDDDK tag (FLAG), MW=73 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Protein arginine methyltransferases (PRMTs) target nuclear and cytoplasmic substrates and can alter protein actions and gene expression. PRMT5, which can methylate histones H2A, H3, and H4, ribonucleoproteins, and other proteins, is upregulated in several human cancers, including lymphomas. Moreover, suppression of...

Protein function: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, PubMed:12411503, PubMed:15737618, PubMed:17709427,...

GSK591 is a chemical probe for protein arginine methyltransferase 5 (PRMT5) that potently inhibits the PRMT5/MEP50 complex from methylating histone H4 (IC50 = 11 nM) in vitro. GSK591 is selective for PRMT5 (up to 50 µM) relative to a panel of other methyltransferases. In Z-138 cells, GSK591 inhibits the symmetric...

LLY-283 is an inhibitor of protein arginine methyltransferase 5 (PRMT5, IC50 = 22 nM). It is selective for PRMT5 over a panel of methyltransferases, including PRMT4, -6, and -7 at 1 µM. It reduces symmetric demethylation of SmBB' in MCF-7 cells (IC50 = 25 nM) and inhibits proliferation of various breast, gastric,...

The PRMT5 Direct Activity Assay kit is designed to measure PRMT5 activity using purified PRMT5 or PRMT5 extracts. The PRMT5 Direct Activity Assay Kit comes in a convenient format, with a 96-well plate precoated with histone H4 peptide substrate, the antibody against methylated arginine residue of Histone H4, the...