91 products were found matching "K02516"!

Protein function: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, PubMed:12411503, PubMed:15737618, PubMed:17709427,...

Protein function: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, PubMed:12411503, PubMed:15737618, PubMed:17709427,...

Description: PRMT5 Protein, Human, Recombinant (Flag & His) is expressed in Baculovirus-Insect Cells. The accession number is O14744-1.

Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and...

PF-06939999 is an inhibitor of protein arginine methyltransferase 5 (PRMT5, Ki = <5 pM). It is selective for PRMT5 over a panel of 22 additional protein methyltransferases and a panel of 40 kinases at 10 µM. PF-06939999 decreases global symmetric dimethyl arginine levels (IC50 = 1. nM) but does not affect histone...

Protein function: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, PubMed:12411503, PubMed:15737618, PubMed:17709427,...

Active human PRMT5 (GenBank Accession No. NM_006109), amino-acids 2-end, with N-terminal DDDDK tag (FLAG), MW=73 kDa, expressed in a FreeStyle 293-F cells.

Active human PRMT5 (GenBank Accession No. NM_006109), amino-acids 2-end, with N-terminal DDDDK tag (FLAG), MW=73 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Protein arginine methyltransferases (PRMTs) target nuclear and cytoplasmic substrates and can alter protein actions and gene expression. PRMT5, which can methylate histones H2A, H3, and H4, ribonucleoproteins, and other proteins, is upregulated in several human cancers, including lymphomas. Moreover, suppression of...

Protein function: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, PubMed:12411503, PubMed:15737618, PubMed:17709427,...

GSK591 is a chemical probe for protein arginine methyltransferase 5 (PRMT5) that potently inhibits the PRMT5/MEP50 complex from methylating histone H4 (IC50 = 11 nM) in vitro. GSK591 is selective for PRMT5 (up to 50 µM) relative to a panel of other methyltransferases. In Z-138 cells, GSK591 inhibits the symmetric...

LLY-283 is an inhibitor of protein arginine methyltransferase 5 (PRMT5, IC50 = 22 nM). It is selective for PRMT5 over a panel of methyltransferases, including PRMT4, -6, and -7 at 1 µM. It reduces symmetric demethylation of SmBB' in MCF-7 cells (IC50 = 25 nM) and inhibits proliferation of various breast, gastric,...