27 products were found matching "K02349"!
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RP 6685
Item number: Cay42127-1
A DNA polymerase theta inhibitor (IC50 = 0.55 nM), selective for DNA polymerase theta over DNA polymerase alpha, -epsilon, -gamma, and -nu (IC50s = >100 µM for all), inhibits double-strand break repair in AAVS1 loci in HCT116 cells (IC50 = 0.5 µM) and the proliferation of HCT116 BRCA2-/- cells (IC50 = 0.32 µM),...
| Keywords: | N-[3-(6-amino-3-pyridazinyl)-2-propyn-1-yl]-N-(4-fluorophenyl)-3,5-bis(trifluoromethyl)-2-pyridineacetamide |
| Application: | DNA polymerase theta inhibitor |
| CAS | 2832047-80-8 |
| MW: | 497.4 D |
From 50.00€
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ART558
Item number: Cay42324-10
ART558 is an inhibitor of DNA polymerase theta (Poltheta, IC50 = 7. nM for Poltheta polymerase activity). It is selective for the polymerase activity of Poltheta over its ATPase activity (IC50 = >12 µM). ART558 (0. 0. and 1 µM) inhibits the repair of DNA double-strand breaks via theta-mediated end joining (TMEJ),...
| Keywords: | (2S,3R)-1-[3-cyano-6-methyl-4-(trifluoromethyl)-2-pyridinyl]-3-hydroxy-N-methyl-N-(3-methylphenyl)-2-pyrrolidinecarboxamide |
| Application: | DNA polymerase theta inhibitor |
| CAS | 2603528-97-6 |
| MW: | 418.41 D |
From 295.00€
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ART812
Item number: Cay42904-1
ART812 is an inhibitor of DNA polymerase theta (IC50 = 7. nM). It inhibits microhomology-mediated end joining (MMEJ) in a reporter assay using HEK293 cells (EC50 = 240 nM). ART812 (150 mg/kg twice per day) increases blood levels of micronucleated reticulocytes in mice. It inhibits tumor development in a Brca1- and...
| Keywords: | (2S,3S,4S)-N-(3-chloro-4-fluorophenyl)-3,4-dihydroxy-N-methyl-1-[6-methyl-4-(trifluoromethyl)-2-pyridinyl]-5-oxo-2-pyrroli... |
| Application: | DNA polymerase theta (POLQ) inhibitor |
| CAS | 2607138-82-7 |
| MW: | 461.8 D |
From 118.00€
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DNA Polymerase theta (POLQ), His-Tag, SUMO-Tag Recombinant
Item number: BPS-101945-1
Recombinant human DNA polymerase theta (Theta), also known as POLQ, encompassing amino acids 1792 to 2590. This construct contains an N-terminal His-tag (6xHis) followed by a thrombin cleavage site and a SUMO-tag. This protein was affinity purified.
| Keywords: | DNA polymerase eta, DNA polymerase theta, DNA Polymerase theta (His-Th-SUMO-1792-2590) |
| Application: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Expressed in: | E.coli |
| Origin: | human |
| MW: | 103 kD |
From 678.00€
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DNA Polymerase theta Assay Kit
Item number: BPS-82107
The DNA Polymerase theta Assay Kit is a fluorogenic assay designed to measure DNA Polymerase theta activity for screening and profiling applications, utilizing the fluorescent nucleic acid dye GroovyGreen(TM) for the quantitation of double-stranded DNA (dsDNA) products. The kit comes in a convenient 96-well format...
| Keywords: | DNA Polymerase Theta, POLQ, |
| Application: | Inhibitor screening, drug discovery, HTS, IC50 determination |
| Species reactivity: | human |
1,292.00€
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DNA polymerase theta (POLQ), partial, human, recombinant
Item number: CSB-BP018321HU1.1
Organism: Homo sapiens (Human). Source: Baculovirus. Expression Region: 1792-2590aa. Protein Length: Partial. Tag Info: C-terminal 6xHis-tagged. Target Protein Sequence: GFKDNSPISD TSFSLQLSQD GLQLTPASSS SESLSIIDVA SDQNLFQTFI KEWRCKKRFS ISLACEKIRS LTSSKTATIG SRFKQASSPQ EIPIRDDGFP IKGCDDTLVV GLAVCWGGRD AYYFSLQKEQ...
| Keywords: | DNA polymerase eta, DNA polymerase theta, Recombinant Human DNA polymerase theta (POLQ), partial |
| Application: | Activity not tested |
| Expressed in: | Insect cells |
| Origin: | human |
| MW: | 92.3 kD |
From 489.00€
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DNA polymerase theta (POLQ), partial, human, recombinant
Item number: CSB-BP018321HU2.1
Organism: Homo sapiens (Human). Source: Baculovirus. Expression Region: 1-987aa. Protein Length: Partial. Tag Info: N-terminal 10xHis-tagged and C-terminal Flag-tagged. Target Protein Sequence: MNLLRRSGKR RRSESGSDSF SGSGGDSSAS PQFLSGSVLS PPPGLGRCLK AAAAGECKPT VPDYERDKLL LANWGLPKAV LEKYHSFGVK KMFEWQAECL LLGQVLEGKN...
| Keywords: | DNA polymerase eta, DNA polymerase theta, Recombinant Human DNA polymerase theta (POLQ), partial |
| Application: | Activity not tested |
| Expressed in: | Insect cells |
| Origin: | human |
| MW: | 112.9 kD |
From 489.00€
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DNA polymerase theta (POLQ), partial, human, recombinant
Item number: CSB-BP018321HU9.1
Organism: Homo sapiens (Human). Source: Baculovirus. Expression Region: 1820-2590aa. Protein Length: Partial. Tag Info: N-terminal 10xHis-tagged and C-terminal Flag-tagged. Target Protein Sequence: SSSESLSIID VASDQNLFQT FIKEWRCKKR FSISLACEKI RSLTSSKTAT IGSRFKQASS PQEIPIRDDG FPIKGCDDTL VVGLAVCWGG RDAYYFSLQK...
| Keywords: | DNA polymerase eta, DNA polymerase theta, Recombinant Human DNA polymerase theta (POLQ), partial |
| Application: | Activity not tested |
| Expressed in: | Insect cells |
| Origin: | human |
| MW: | 90.2 kD |
From 489.00€
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DNA polymerase theta (POLQ), partial, human, recombinant
Item number: CSB-EP018321HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 321-554aa. Protein Length: Partial. Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged. Target Protein Sequence: GDEDHVVSLC YETICDNHSV LLFCPSKKWC EKLADIIARE FYNLHHQAEG LVKPSECPPV ILEQKELLEV MDQLRRLPSG LDSVLQKTVP WGVAFHHAGL TFEERDIIEG...
| Keywords: | DNA polymerase eta, DNA polymerase theta, Recombinant Human DNA polymerase theta (POLQ), partial |
| Application: | Activity not tested |
| Expressed in: | E.coli |
| Origin: | human |
| MW: | 33.3 kD |
From 292.00€
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DNA polymerase theta (POLQ), partial, human, recombinant
Item number: CSB-EP018321HU1.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 1792-2590aa. Protein Length: Partial. Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged. Target Protein Sequence: GFKDNSPISD TSFSLQLSQD GLQLTPASSS SESLSIIDVA SDQNLFQTFI KEWRCKKRFS ISLACEKIRS LTSSKTATIG SRFKQASSPQ EIPIRDDGFP IKGCDDTLVV...
| Keywords: | DNA polymerase eta, DNA polymerase theta, Recombinant Human DNA polymerase theta (POLQ), partial |
| Application: | Activity not tested |
| Expressed in: | E.coli |
| Origin: | human |
| MW: | 96.9 kD |
From 292.00€
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DNA polymerase theta (POLQ), partial, human, recombinant
Item number: CSB-EP018321HU9.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 1820-2590aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-SUMO-tagged. Target Protein Sequence: SSSESLSIID VASDQNLFQT FIKEWRCKKR FSISLACEKI RSLTSSKTAT IGSRFKQASS PQEIPIRDDG FPIKGCDDTL VVGLAVCWGG RDAYYFSLQK EQKHSEISAS LVPPSLDPSL TLKDRMWYLQ...
| Keywords: | DNA polymerase eta, DNA polymerase theta, Recombinant Human DNA polymerase theta (POLQ), partial |
| Application: | Activity not tested |
| Expressed in: | E.coli |
| Origin: | human |
| MW: | 99.5 kD |
From 292.00€
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DNA polymerase theta (POLQ), partial, human, recombinant
Item number: CSB-EP018321HU9c7.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 1820-2590aa. Protein Length: Partial. Tag Info: C-terminal 6xHis-tagged. Target Protein Sequence: SSSESLSIID VASDQNLFQT FIKEWRCKKR FSISLACEKI RSLTSSKTAT IGSRFKQASS PQEIPIRDDG FPIKGCDDTL VVGLAVCWGG RDAYYFSLQK EQKHSEISAS LVPPSLDPSL TLKDRMWYLQ...
| Keywords: | DNA polymerase eta, DNA polymerase theta, Recombinant Human DNA polymerase theta (POLQ), partial |
| Expressed in: | E.coli |
| Origin: | human |
| MW: | 87.5 kD |
From 292.00€
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