19 products were found matching "K02320"!

Cytarabine (ara-C) is a nucleoside analog and prodrug form of the DNA polymerase inhibitor ara-CTP. It is triphosphorylated to ara-CTP by the successive actions of deoxycytidine kinase, deoxycytidylate kinase, and nucleoside diphosphate kinase. Ara-C inhibits proliferation of HL-60, ML-1, Raji, and Jurkat human...

Antibiotic, Reversible inhibitor of eukaryotic nuclear DNA replication, Useful for cell synchronization, Blocks the cell cycle at early S phase, Prolongs the half life of DNA methyltransferase, Specific DNA polymerase alpha and delta inhibitor in eukaryotic cells and in some viruses of animal origin, Acts...

CX-5461 is an inhibitor of ribosomal RNA (rRNA) synthesis. It selectively inhibits RNA polymerase I-driven transcription of rRNA in HCT116, A375, and MIA PaCa-2 tumor cells (IC50s = 142, 113, and 54 nM, respectively) without affecting RNA polymerase II (IC50 > 25µM), DNA replication, or protein translation. At 50...

Protein function: Plays an essential role in the initiation of DNA replication. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1/p180, a regulatory subunit POLA2/p70 and two primase subunits PRIM1/p49 and PRIM2/p58) is recruited to DNA at the replicative...

White solid. A DNA polymerase inhibitor. Potentiates apoptosis induced by therapeutic nucleosides.

Cytarabine is an antimetabolite compound which is proven to be one of the most effective agents available to treat leukemia. It induces its cytotoxic effect by inactivating DNA polymerases alpha, delta, and epsilon and consequently inhibit semi-conservative DNA replication and repair. It also has a potential to...

Protein function: Plays an essential role in the initiation of DNA replication. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1/p180, a regulatory subunit POLA2/p70 and two primase subunits PRIM1/p49 and PRIM2/p58) is recruited to DNA at the replicative...

Cytarabine-13C3 (ara-C-13C3) is intended for use as an internal standard for the quantification of ara-C (Cay-16069) by GC- or LC-MS. Ara-C is a nucleoside analog and prodrug form of the DNA polymerase inhibitor ara-CTP. It is triphosphorylated to ara-CTP by the successive actions of deoxycytidine kinase,...

White to off-white solid. Soluble in DMSO or methanol. Phytotoxin (inhibits root growth of seeding), specific inhibitor of eukaryotic DNA polymerase alpha and DNA synthesis (competition with dCTP).

POLA1 Antibody from Assay Genie with reactivity against Human and for use in ELISA, WB applications. POLA1 Antibody is Polyclonal and is a IgG isotype antibody from Assay Genie.. Protein function: Catalytic subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which...

POLA1 Antibody is a IgG polyclonal antibody from Assay Genie with reactivity against Human and for use in ELISA, WB applications. POLA1 Antibody is a high quality polyclonal antibody for research use only.. Protein function: Catalytic subunit of the DNA polymerase alpha complex (also known as the alpha DNA...

Protein function: Catalytic subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, a...