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Item number: Cay13305-5

D 4476 is a cell-permeant inhibitor of casein kinase 1 (CK1, IC50 = 200 nM from S. pombe, 300 nM for CK1delta). It is a less effective inhibitor of PKD1 (IC50 = 9.1 µM) and p38alpha MAPK (IC50 = 5.8 µM), and only weakly affects the activities of a panel of kinases tested. D 4476 blocks CK1-mediated phosphorylation...

Keywords:	Casein Kinase I Inhibitor, 4-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-(2-pyridinyl)1H-imidazol-2-yl]-benzamide
Application:	CK1 inhibitor
CAS	301836-43-1
MW:	398.4 D

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