41 products were found matching "K02166"!

An inhibitor of sFRP1 (IC50 = 0.5 µM), increases Wnt signaling in U2OS osteosarcoma cells (EC50 = 0.65 µM), increases total bone area in a murine calvarial organ culture assay at 0.1 nM. SMILES: O=S(C1=CC=CC=C1)(C2=CC=C(C(F)(F)F)C(S(NC3CCNCC3)(=O)=O)=C2)=O. InChi Code:...

Secreted frizzled-related protein 1 (SFRP1) is a gene that belongs to the secreted glycoprotein SFRP family. SFRP1 has been classified as a tumor suppressor gene due to the loss of expression in various human cancers, which is mainly attributed by epigenetic inactivation via DNA methylation or transcriptional...

Protein function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels. Has antiproliferative effects on vascular...

This affinity purified antibody is directed against human SFRP protein. The product was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest reactivity with this protein from human based on 100% homology for the immunogen sequence. Expect cross reactivity...

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Secreted frizzled-related protein 1 Protein function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in...

This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling, epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is...

WAY-316606 is an inhibitor of secreted frizzled-related protein 1 (sFRP1, IC50 = 0.5 µM). It increases Wnt signaling in U2OS osteosarcoma cells (EC50 = 0.65 µM). WAY-316606 increases total bone area in a murine calvarial organ culture assay when used at concentrations greater than 0.1 nM.Formal Name:...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Secreted frizzled-related protein 1, also known as SFRP1, is a protein which in humans is encoded by the SFRP1 gene. It is mapped to 8p11.21. This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative...

Protein function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels. Has antiproliferative effects on vascular...

Protein function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels. Has antiproliferative effects on vascular...

Secreted frizzled-related protein 1 (sFRP1) is a Wnt inhibitor and a member of the sFRP family. It is composed of a signal peptide, a cysteine-rich domain, and a netrin-like domain. sFRP1 is ubiquitously expressed, with the highest levels in the heart, ovary, testis, and small intestine. It inhibits Wnt signaling by...