42 products were found matching "K02163"!

Protein function: Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX [The UniProt Consortium]

Formulation: Purified Ab with BSA and Azide at 200ug/ml. Cellular Localization: Mitochondrion membrane. Positive Control: A-431, FaDu, HEK293, Hep G2, MCF7 or U87 cells., PC-3. Chromosome Location: 14q11.2. Protein Function: Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of...

Formulation: Purified Ab WITHOUT BSA and Azide at 1.0mg/ml. Cellular Localization: Mitochondrion membrane. Positive Control: A-431, FaDu, HEK293, Hep G2, MCF7 or U87 cells., PC-3. Chromosome Location: 14q11.2. Protein Function: Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of...

Formulation: Purified Ab with BSA and Azide at 200ug/ml. Cellular Localization: Mitochondrion membrane. Positive Control: HEK293, HePG2, MCF-7 or U87 cells., PC-3. Chromosome Location: 14q11.2-q12. Protein Function: Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic...

Formulation: Purified Ab WITHOUT BSA and Azide at 1.0mg/ml. Cellular Localization: Mitochondrion membrane. Positive Control: HEK293, HePG2, MCF-7 or U87 cells., PC-3. Chromosome Location: 14q11.2-q12. Protein Function: Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Bcl-2-like protein 2 is a protein that in humans is encoded by the BCL2L2 gene. This gene encodes a pro-survival (anti-apoptotic) member of the bcl-2 protein family. Its is mapped to human chromosome 14q11.2-q12. The protein can be found in brain, colon and...

Obatoclax is an antagonist of Bcl-2 family members containing four Bcl-2 homology domains, including Bcl-2, Bcl-W, Bcl-xL, and Mcl-1 (Kd = ~500 nM). It prevents the interaction of these pro-survival proteins with Bax or Bak, thereby inducing apoptosis with up-regulation of Bim, induced cytochrome c release, and...

HA-14-1 is a small molecule that binds the surface pocket of Bcl-2 proteins (IC50 = ~ 9 µM) and induces apoptosis by interfering with its interaction with the Bak peptide and activating Apaf-1 and caspase-9 and -3. It can also bind to the antiapoptotic Bcl-2 proteins Bcl-xl and Bcl-W. HA-14-1 has been shown to...

ABT-263 is a BH3 mimetic that inhibits Bcl-2 and Bcl-xl. ABT-263's inhibition of Bcl-xl results in thrombocytopenia, limiting its usage. ABT-263 exhibits anticancer chemotherapeutic activity and shows some benefit in clinical trials. In chronic lymphocytic leukemia (CLL) cells, ABT-263 inhibits cell proliferation....

Protein function: Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX. [The UniProt Consortium]

The BCL2L2 TR-FRET Assay Kit is designed to measure the inhibition of BCL2L2 (BCL-w) binding to its ligand in a homogeneous 384 reaction format. This FRET-based assay requires no time-consuming washing steps, making it especially suitable for high throughput screening applications. The assay procedure is...

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide. Bcl2L2, also called BCLW, promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX. Protein function: Promotes cell survival. Blocks...