16 products were found matching "K02146"!

Bafilomycin A1 is a bacterial metabolite that has been found in Streptomyces and has diverse biological activities. It is an inhibitor of vacuolar H+-ATPases (V-ATPases, Ki = 0.5 nM in N. crassa vacuolar membranes) and is greater than 1,000-fold selective for V-ATPases over Na+/K+-, Ca2+-, and H+-ATPases....

Concanamycin A is a plecomacrolide antibiotic that has been found in Streptomyces. It is active against S. cerevisiae, S. sake, A. citri, P. citrinum, and P. oryzae (MICs = +-ATPase (V-ATPase, EC50 = ~2.1-2.3 µM). It also decreases perforin levels in CD8+ OE4 cytotoxic T lymphocytes (CTLs). Concanamycin A (100 µM)...

Concanamycin B is a macrolide antibiotic originally isolated from Streptomyces that selectively inhibits vacuolar type H+-ATPases, also known as V-ATPases (IC50 = 5 nM). In this way, it blocks the acidification of vacuolar organelles as well as early to late endosomal transport. Concanamycin B interferes with bone...

Protein function: Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton...

ATP6V0D2 Antibody is a IgG polyclonal antibody from Assay Genie with reactivity against Human and for use in ELISA, WB, IHC, IF applications. ATP6V0D2 Antibody is a high quality polyclonal antibody for research use only.. Protein function: Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar...

Protein function: Subunit of the integral membrane V0 complex of the lysosomal proton-transporting V-type ATPase (v-ATPase) (PubMed:28296633, PubMed:30374053). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport...

Protein function: Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton...

function:Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton...

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and...

V-type proton ATPase subunit d 2 (UniProt Q80SY3, also known as Osteoclast-specific vacuolar ATP synthase, V-ATPase subunit d 2, Vacuolar proton pump subunit d 2) is encoded by the Atp6v0d2 gene (Gene ID 242341) in murine species. V-ATPase is a proton pump consists of an 8-subunit (subunit A through H) peripheral...

Macrolide lactone antibiotic.